Literature DB >> 3021036

Non-Hodgkin's lymphoma after treatment of Hodgkin's disease: association with Epstein-Barr virus.

A F List, J P Greer, J B Cousar, R S Stein, J M Flexner, F Sinangil, J Davis, D J Volsky, D T Purtilo.   

Abstract

Non-Hodgkin's lymphoma occurs infrequently as a late complication of obscure cause after treatment of Hodgkin's disease. We investigated the possible role of Epstein-Barr virus in the pathogenesis of such secondary malignancies of B-cell lineage. Two patients, aged 25 and 43 years, developed high-grade non-Hodgkin's lymphomas 12 and 8 years after radiation therapy for Hodgkin's disease. Serologic profiles in these patients showed evidence of acute and past Epstein-Barr virus infections, respectively. Molecular hybridization analysis showed the presence of multiple cellular equivalents of virus genome in tumor specimens from each patient. Our findings suggest that Epstein-Barr virus may play an integral role in the pathogenesis of non-Hodgkin's lymphoma of B-cell lineage that develops after treatment of Hodgkin's disease.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3021036     DOI： 10.7326/0003-4819-105-5-668

Source DB:  PubMed          Journal:  Ann Intern Med        ISSN： 0003-4819            Impact factor:   25.391


  6 in total

1.  Increased risk of second cancers in managing Hodgkins disease: the 20-year Leiden experience.

Authors:  J K Sont; W A van Stiphout; E M Noordijk; J Molenaar; J H Zwetsloot-Schonk; R Willemze; J P Vandenbroucke
Journal:  Ann Hematol       Date:  1992-11       Impact factor: 3.673

2.  The detection of Epstein-Barr virus in hairy cell leukemia cells by in situ hybridization.

Authors:  B C Wolf; A W Martin; R S Neiman; A J Janckila; L T Yam; A Caracansi; B A Leav; R Winpenny; D S Schultz; H J Wolfe
Journal:  Am J Pathol       Date:  1990-03       Impact factor: 4.307

3.  Monomorphic lymphomas arising in patients with Hodgkin's disease. Correlation of morphologic, immunophenotypic, and molecular genetic findings in 12 cases.

Authors:  T T Casey; J B Cousar; M Mangum; M E Williams; J T Lee; J P Greer; R D Collins
Journal:  Am J Pathol       Date:  1990-01       Impact factor: 4.307

4.  Colonic lymphoma in the transplant patient.

Authors:  D L Phillips; E B Keeffe; K G Benner; R M Braziel
Journal:  Dig Dis Sci       Date:  1989-01       Impact factor: 3.199

Review 5.  Some aspects of the etiology of non-Hodgkin's lymphoma.

Authors:  L Hardell; G Lindström; B van Bavel; M Fredrikson; G Liljegren
Journal:  Environ Health Perspect       Date:  1998-04       Impact factor: 9.031

Review 6.  Second malignancies in Hodgkin's disease: A review of the literature and report of a case with a secondary Lennert's lymphoma.

Authors:  Ernst Jg Norval; Erich J Raubenheimer
Journal:  J Oral Maxillofac Pathol       Date:  2014-09
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.