A Linneberg1, J Petersen, M Grønbaek, C S Benn. 1. Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark. alli@glostruphosp.kbhamt.dk
Abstract
BACKGROUND: There is evidence that antenatal factors play a role in the development of atopic dermatitis (AD). However, little is known about the effects of maternal lifestyle factors during pregnancy on the risk of AD in the offspring. OBJECTIVE: To investigate the effect of alcohol consumption during pregnancy on the incidence of AD in the offspring. METHODS: A total of 24 341 mother-child pairs enrolled in the Danish National Birth Cohort were followed prospectively. Information about alcohol consumption was obtained by interview at 12 and 30 weeks of gestation. Information about symptoms, time of onset, and doctor's diagnosis of AD in the offspring was obtained by interview at 18 months of age. The effect of alcohol consumption during pregnancy on the incidence of AD was analysed by Cox regression allowing for different effects of alcohol before (early infancy) and after 2 months (60 days) of age. RESULTS: Alcohol during pregnancy was associated with a significant and dose-dependent increased risk of AD in early infancy. This effect was mainly seen in high-risk infants (two parents with allergic disease). Thus, the highest risk of AD in early infancy was seen in high-risk infants of mothers who consumed four or more drinks per week at 30 weeks of gestation (adjusted relative risk 4.2, 95% confidence interval 1.7-10.1). There was no effect of alcohol during pregnancy beyond early infancy. CONCLUSIONS: The results suggest that alcohol during pregnancy increases the risk of early-onset AD in predisposed infants.
BACKGROUND: There is evidence that antenatal factors play a role in the development of atopic dermatitis (AD). However, little is known about the effects of maternal lifestyle factors during pregnancy on the risk of AD in the offspring. OBJECTIVE: To investigate the effect of alcohol consumption during pregnancy on the incidence of AD in the offspring. METHODS: A total of 24 341 mother-child pairs enrolled in the Danish National Birth Cohort were followed prospectively. Information about alcohol consumption was obtained by interview at 12 and 30 weeks of gestation. Information about symptoms, time of onset, and doctor's diagnosis of AD in the offspring was obtained by interview at 18 months of age. The effect of alcohol consumption during pregnancy on the incidence of AD was analysed by Cox regression allowing for different effects of alcohol before (early infancy) and after 2 months (60 days) of age. RESULTS:Alcohol during pregnancy was associated with a significant and dose-dependent increased risk of AD in early infancy. This effect was mainly seen in high-risk infants (two parents with allergic disease). Thus, the highest risk of AD in early infancy was seen in high-risk infants of mothers who consumed four or more drinks per week at 30 weeks of gestation (adjusted relative risk 4.2, 95% confidence interval 1.7-10.1). There was no effect of alcohol during pregnancy beyond early infancy. CONCLUSIONS: The results suggest that alcohol during pregnancy increases the risk of early-onset AD in predisposed infants.
Authors: Anders Glynn; Ann Thuvander; Marie Aune; Anders Johannisson; Per Ola Darnerud; Gunnar Ronquist; Sven Cnattingius Journal: Environ Health Date: 2008-12-04 Impact factor: 5.984
Authors: Carina Venter; Carlo Agostoni; S Hasan Arshad; Miriam Ben-Abdallah; George Du Toit; David M Fleischer; Matthew Greenhawt; Deborah H Glueck; Marion Groetch; Nonhlanhla Lunjani; Kate Maslin; Alexander Maiorella; Rosan Meyer; Muraro Antonella; Merryn J Netting; Bright Ibeabughichi Nwaru; Debra J Palmer; Micheala P Palumbo; Graham Roberts; Caroline Roduit; Pete Smith; Eva Untersmayr; Lauren A Vanderlinden; Liam O'Mahony Journal: Pediatr Allergy Immunol Date: 2020-08-06 Impact factor: 5.464
Authors: Charlotte Giwercman Carson; Liselotte Brydensholt Halkjaer; Signe Marie Jensen; Hans Bisgaard Journal: PLoS One Date: 2012-08-15 Impact factor: 3.240
Authors: Tea Skaaby; Tuomas O Kilpeläinen; Amy E Taylor; Yuvaraj Mahendran; Andrew Wong; Tarunveer S Ahluwalia; Lavinia Paternoster; Stella Trompet; David J Stott; Claudia Flexeder; Ang Zhou; Guy Brusselle; Ayesha Sajjad; Lies Lahousse; Henning Tiemeier; Christian Theil Have; Betina H Thuesen; Line Lund Kårhus; Line Tang Møllehave; Katja Biering Leth-Møller; Daniel Mønsted Shabanzadeh; Arturo Gonzalez-Quintela; Chris Power; Elina Hyppönen; Diana Kuh; Rebecca Hardy; Thomas Meitinger; J Wouter Jukema; Uwe Völker; Matthias Nauck; Henry Völzke; Nele Friedrich; Tobias N Bonten; Raymond Noordam; Dennis O Mook-Kanamori; Janne S Tolstrup; Christian Taube; Annette Peters; Harald Grallert; Konstantin Strauch; Holger Schulz; Niels Grarup; Torben Hansen; Oluf Pedersen; Stephen Burgess; Marcus R Munafò; Allan Linneberg Journal: Addiction Date: 2018-10-30 Impact factor: 7.256
Authors: Gabrielle A Lockett; Veeresh K Patil; Nelís Soto-Ramírez; Ali H Ziyab; John W Holloway; Wilfried Karmaus Journal: Epigenomics Date: 2013-12 Impact factor: 4.778