I Muraskaite1, S Koscielny2, M Komann3, C Weinmann3, W Meißner3. 1. Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland. ieva.muraskaite@med.uni-jena.de. 2. Klinik und Poliklinik für HNO-Heilkunde, Universitätsklinikum Jena, Jena, Deutschland. 3. Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.
Abstract
BACKGROUND: In the context of improving perioperative pain management and shortening hospital stays, potent oral analgesics, such as slow release opioids, are gaining increasingly in importance. OBJECTIVE: The aim of this study was to compare the use and effectiveness of different opioids in postoperative pain treatment in Germany. MATERIALS AND METHODS: Using data from the QUIPS database, the records of 5249 patients were evaluated. The total study population was divided into four groups: group 1 (10 mg oxycodone with or without naloxone 5 mg), group 2 (20 mg oxycodone with or without naloxone 10 mg), group 3 (piritramide) and group 4 (tramadol). Maximum pain intensity, pain-related interference with sleep and respiration, vomiting, postoperative fatigue, desire for more pain treatment and satisfaction with pain management were evaluated. RESULTS AND DISCUSSION: The differences in pain intensity were statistically significant between groups. Patients with piritramide reported more pain, more interference with sleep and respiration and more fatigue compared to those from the other groups. In the group with 10 mg oxycodone, the desire for additional pain medication was the lowest. Postoperative vomiting and satisfaction with pain management differed significantly between the four groups. Procedure-specific analysis has shown that differences between sub-groups were also significant following cholecystectomy and total knee arthroplasty. CONCLUSIONS: In summary, our findings suggest that postoperative pain treatment with slow release oral oxycodone does not show disadvantages compared to tramadol or piritramide with regard to pain-related impairments and opioid-induced side effects. This hypothesis needs to be further analyzed in controlled studies.
BACKGROUND: In the context of improving perioperative pain management and shortening hospital stays, potent oral analgesics, such as slow release opioids, are gaining increasingly in importance. OBJECTIVE: The aim of this study was to compare the use and effectiveness of different opioids in postoperative pain treatment in Germany. MATERIALS AND METHODS: Using data from the QUIPS database, the records of 5249 patients were evaluated. The total study population was divided into four groups: group 1 (10 mg oxycodone with or without naloxone 5 mg), group 2 (20 mg oxycodone with or without naloxone 10 mg), group 3 (piritramide) and group 4 (tramadol). Maximum pain intensity, pain-related interference with sleep and respiration, vomiting, postoperative fatigue, desire for more pain treatment and satisfaction with pain management were evaluated. RESULTS AND DISCUSSION: The differences in pain intensity were statistically significant between groups. Patients with piritramide reported more pain, more interference with sleep and respiration and more fatigue compared to those from the other groups. In the group with 10 mg oxycodone, the desire for additional pain medication was the lowest. Postoperative vomiting and satisfaction with pain management differed significantly between the four groups. Procedure-specific analysis has shown that differences between sub-groups were also significant following cholecystectomy and total knee arthroplasty. CONCLUSIONS: In summary, our findings suggest that postoperative pain treatment with slow release oral oxycodone does not show disadvantages compared to tramadol or piritramide with regard to pain-related impairments and opioid-induced side effects. This hypothesis needs to be further analyzed in controlled studies.
Entities:
Keywords:
Acute pain management; Opioids; Oral application; QUIPS; Side effects
Authors: Justin de V de Beer; Mitchell J Winemaker; Graeme A E Donnelly; Paula C Miceli; Joseph L Reiz; Zoltan Harsanyi; Lance W Payne; Andrew C Darke Journal: Can J Surg Date: 2005-08 Impact factor: 2.089
Authors: Winfried Meißner; Marcus Komann; Joachim Erlenwein; Ulrike Stamer; André Scherag Journal: Dtsch Arztebl Int Date: 2017-03-10 Impact factor: 5.594
Authors: Christoph Maier; Nadja Nestler; Helmut Richter; Winfried Hardinghaus; Esther Pogatzki-Zahn; Michael Zenz; Jürgen Osterbrink Journal: Dtsch Arztebl Int Date: 2010-09-10 Impact factor: 5.594