Amy C Alman1, Jennifer W Talton2, R Paul Wadwa3, Elaine M Urbina4, Lawrence M Dolan4, Richard F Hamman5, Ralph B D'Agostino2, Santica M Marcovina6, Dana M Dabelea5. 1. Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, USA. Electronic address: aalman@health.usf.edu. 2. Department of Biostatistical Sciences, Wake Forest School of Medicine, USA. 3. Barbara Davis Center, University of Colorado Denver, USA. 4. Department of Pediatrics, Cincinnati Children's Hospital Medical Center, USA. 5. Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, USA. 6. Department of Metabolism, Endocrinology and Nutrition, University of Washington, USA.
Abstract
AIMS: We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D). METHODS: A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline. Measures of PWV were repeated approximately five years later. RESULTS: PWV-R (0.50 m/s), PWV-T (0.65 m/s), and PWV-LE (1.0 m/s) significantly increased over the follow-up (p < 0.001 for each). A significant interaction was found between waist circumference and fibrinogen (p = 0.036) on the progression of PWV-T, suggesting that fibrinogen is more strongly associated with PWV progression in lean participants. CONCLUSIONS: Improved understanding of adiposity, inflammation, and functional changes in the vascular system in patients with T1D is crucial.
AIMS: We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D). METHODS: A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline. Measures of PWV were repeated approximately five years later. RESULTS: PWV-R (0.50 m/s), PWV-T (0.65 m/s), and PWV-LE (1.0 m/s) significantly increased over the follow-up (p < 0.001 for each). A significant interaction was found between waist circumference and fibrinogen (p = 0.036) on the progression of PWV-T, suggesting that fibrinogen is more strongly associated with PWV progression in lean participants. CONCLUSIONS: Improved understanding of adiposity, inflammation, and functional changes in the vascular system in patients with T1D is crucial.
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