| Literature DB >> 30207951 |
Mohamed A Naser, Diego R T Sampaio, Nina M Munoz, Cayla A Wood, Trevor M Mitcham, Wolfgang Stefan, Konstantin V Sokolov, Theo Z Pavan, Rony Avritscher, Richard R Bouchard.
Abstract
As photoacoustic (PA) imaging makes its way into the clinic, the accuracy of PA-based metrics becomes increasingly important. To address this need, a method combining finite-element-based local fluence correction (LFC) with signal-to-noise-ratio (SNR) regularization was developed and validated to accurately estimate oxygen saturation (SO2) in tissue. With data from a Vevo LAZR system, performance of our LFC approach was assessed in ex vivo blood targets (37.6%-99.6% SO2) and in vivo rat arteries. Estimation error of absolute SO2 and change in SO2 reduced from 10.1% and 6.4%, respectively, without LFC to 2.8% and 2.0%, respectively, with LFC, while the accuracy of the LFC method was correlated with the number of wavelengths acquired. This paper demonstrates the need for an SNR-regularized LFC to accurately quantify SO2 with PA imaging.Entities:
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Year: 2018 PMID： 30207951 PMCID： PMC6445252 DOI： 10.1109/TMI.2018.2867602
Source DB: PubMed Journal: IEEE Trans Med Imaging ISSN： 0278-0062 Impact factor: 10.048