Literature DB >> 30203401

Time-Course Changes and New Expressions of MIP-3α and Its Receptor, CCR6, in the Gerbil Hippocampal CA1 Area Following Transient Global Cerebral Ischemia.

Joon Ha Park1, YooHun Noh2, Sung-Su Kim2, Ji Hyeon Ahn1, Taek Geun Ohk3, Jun Hwi Cho3, Tae-Kyeong Lee4, Hyunjung Kim4, Minah Song4, Jae-Chul Lee4, Moo-Ho Won5, Choong-Hyun Lee6.   

Abstract

Macrophage inflammatory protein-3α (MIP-3α) and its sole receptor, CCR6, play pivotal roles in neuroinflammatory processes induced by brain ischemic insults. In this study, we investigated transient ischemia-induced changes in MIP-3α and CCR6 protein expressions in the hippocampal CA1 area following 5 min of transient global cerebral ischemia (tgCI) in gerbils. Both MIP-3α and CCR6 immunoreactivities were very strongly expressed in pyramidal neurons of the CA1 area from 6 h to 1 day after tgCI and were hardly shown 4 days after tgCI. In addition, strong MIP-3α immunoreactivity was newly expressed in astrocytes 6 h after tgCI. These results indicate that tgCI causes apparent changes in MIP-3α and CCR6 expressions in pyramidal neurons and astrocytes in the hippocampal CA1 area and suggest that tgCI-induced changes in MIP-3α and CCR6 expressions might be closely associated with neuroinflammatory processes in brain ischemic regions.

Entities:  

Keywords:  CCR6; Gerbil; Macrophage inflammatory protein-3α; Neuroinflammation; Neuronal death; Transient global cerebral ischemia

Mesh：

Substances：

Year:  2018        PMID： 30203401     DOI： 10.1007/s11064-018-2632-6

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  42 in total

Review 1.  Pathobiology of ischaemic stroke: an integrated view.

Authors:  U Dirnagl; C Iadecola; M A Moskowitz
Journal:  Trends Neurosci       Date:  1999-09       Impact factor: 13.837

Review 2.  Mechanisms of ischemic brain damage.

Authors:  Kristian P Doyle; Roger P Simon; Mary P Stenzel-Poore
Journal:  Neuropharmacology       Date:  2008-01-25       Impact factor: 5.250

3.  New expression of 5-HT1A receptor in astrocytes in the gerbil hippocampal CA1 region following transient global cerebral ischemia.

Authors:  Choong Hyun Lee; Ji Hyeon Ahn; Moo-Ho Won
Journal:  Neurol Sci       Date:  2014-09-25       Impact factor: 3.307

4.  Therapeutic time window of post-ischemic mild hypothermia and the gene expression associated with the neuroprotection in rat focal cerebral ischemia.

Authors:  Hiroyuki Ohta; Yasuko Terao; Yasushi Shintani; Yoshihiro Kiyota
Journal:  Neurosci Res       Date:  2007-01-08       Impact factor: 3.304

5.  Altered expression of neuronal CCR6 during pilocarpine induced status epilepticus in mice.

Authors:  Jian-Xin Liu; Xia Cao; Yong Liu; Feng-Ru Tang
Journal:  Epilepsy Res       Date:  2016-06-26       Impact factor: 3.045

6.  Early increases in TNF-alpha, IL-6 and IL-1 beta levels following transient cerebral ischemia in gerbil brain.

Authors:  K Saito; K Suyama; K Nishida; Y Sei; A S Basile
Journal:  Neurosci Lett       Date:  1996-03-15       Impact factor: 3.046

7.  Differences in neuronal damage and gliosis in the hippocampus between young and adult gerbils induced by long duration of transient cerebral ischemia.

Authors:  Bing Chun Yan; Taek Geun Ohk; Ji Hyeon Ahn; Joon Ha Park; Bai Hui Chen; Jae-Chul Lee; Choong Hyun Lee; Myoung Cheol Shin; In Koo Hwang; Seung Myung Moon; Jun Hwi Cho; Moo-Ho Won
Journal:  J Neurol Sci       Date:  2013-12-01       Impact factor: 3.181

8.  Macrophage inflammatory protein-3alpha plays a key role in the inflammatory cascade in rat focal cerebral ischemia.

Authors:  Yasuko Terao; Hiroyuki Ohta; Akira Oda; Yumiko Nakagaito; Yoshihiro Kiyota; Yasushi Shintani
Journal:  Neurosci Res       Date:  2009-02-13       Impact factor: 3.304

9.  Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells.

Authors:  Yong Chen; John M Hallenbeck; Christl Ruetzler; David Bol; Karen Thomas; Nancy E J Berman; Stefanie N Vogel
Journal:  J Cereb Blood Flow Metab       Date:  2003-06       Impact factor: 6.200

10.  Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat.

Authors:  J S Kim; S C Gautam; M Chopp; C Zaloga; M L Jones; P A Ward; K M Welch
Journal:  J Neuroimmunol       Date:  1995-02       Impact factor: 3.478
View more
  5 in total

Review 1.  Estrogenic hormones receptors in Alzheimer's disease.

Authors:  Angeles C Tecalco-Cruz; Jesús Zepeda-Cervantes; Bibiana Ortega-Domínguez
Journal:  Mol Biol Rep       Date:  2021-10-16       Impact factor: 2.316

2.  Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus.

Authors:  Ji Hyeon Ahn; Joon Ha Park; Tae-Kyung Lee; Go Eun Yang; Myoung Cheol Shin; Jun Hwi Cho; Moo-Ho Won; Choong-Hyun Lee
Journal:  Mol Med Rep       Date:  2020-06-09       Impact factor: 2.952

3.  Altered Nurr1 protein expression in the hippocampal CA1 region following transient global cerebral ischemia.

Authors:  Joon Ha Park; Ji Hyeon Ahn; Dae Won Kim; Tae-Kyeong Lee; Cheol Woo Park; Young Eun Park; Jae-Chul Lee; Hyang-Ah Lee; Go Eun Yang; Moo-Ho Won; Choong-Hyun Lee
Journal:  Mol Med Rep       Date:  2019-11-20       Impact factor: 2.952

4.  Change of Nurr1 expression in mouse hippocampal CA3 region following excitotoxic neuronal damage.

Authors:  Choong-Hyun Lee
Journal:  Iran J Basic Med Sci       Date:  2020-02       Impact factor: 2.699

5.  High-Mobility Group Box 1 Contributes to Cerebral Cortex Injury in a Neonatal Hypoxic-Ischemic Rat Model by Regulating the Phenotypic Polarization of Microglia.

Authors:  Yanyan Sun; Mingyan Hei; Zhihui Fang; Zhen Tang; Bo Wang; Na Hu
Journal:  Front Cell Neurosci       Date:  2019-12-11       Impact factor: 5.505
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.