Literature DB >> 25253632

New expression of 5-HT1A receptor in astrocytes in the gerbil hippocampal CA1 region following transient global cerebral ischemia.

Choong Hyun Lee1, Ji Hyeon Ahn, Moo-Ho Won.   

Abstract

5-Hydroxytryptamine (5-HT, serotonin) plays protective or detrimental roles in the development of ischemic damage. In the present study, we investigated the time-course changes in 5-HT1A receptor protein expression in the gerbil hippocampal CA1 region after transient global cerebral ischemia. 5-HT1A receptor immunoreactivity in the stratum pyramidale (SP) of the CA1 region was decreased from 6 h and hardly observed 1 and 2 days after ischemic insult. Five and 10 days after ischemia/reperfusion, 5-HT1A receptor immunoreactivity was increased and detected in astrocyte of the ischemic CA1 region. Furthermore, the pattern of changes in 5-HT1A receptor protein levels in the CA1 region after ischemia-reperfusion was similar to that observed in the immunohistochemical data. These results indicate that 5-HT1A receptor protein expressions may be related with the ischemia-induced neuronal death and the function of astrocytes in the ischemic hippocampal CA1 region.

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Year:  2014        PMID： 25253632     DOI： 10.1007/s10072-014-1958-3

Source DB:  PubMed          Journal:  Neurol Sci        ISSN： 1590-1874            Impact factor:   3.307


  20 in total

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4.  Cellular localization of the 5-HT1A receptor in primate brain neurons and glial cells.

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Journal:  Brain Res       Date:  1985-11-04       Impact factor: 3.252

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Authors:  T Kirino
Journal:  Brain Res       Date:  1982-05-06       Impact factor: 3.252

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  5 in total

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Journal:  Neurochem Res       Date:  2017-03-28       Impact factor: 3.996

2.  Electroacupuncture ameliorates learning and memory deficits via hippocampal 5-HT1A receptors and the PKA signaling pathway in rats with ischemic stroke.

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Journal:  Neurochem Res       Date:  2018-09-10       Impact factor: 3.996

4.  Protective Effects of 5-HT1A Receptor Inhibition and 5-HT2A Receptor Stimulation Against Streptozotocin-Induced Apoptosis in the Hippocampus.

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5.  Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia.

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  5 in total

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