Jancineide Oliveira de Carvalho1,2,3, Francilio de Carvalho Oliveira1,2, Sérgio Antonio Pereira Freitas2, Liana Martha Soares4, Rita de Cássia Barros Lima2, Licia de Sousa Gonçalves2, Thomas Jay Webster5, Fernanda Roberta Marciano1,5, Anderson Oliveira Lobo6,7,8. 1. Instituto de Ciência e Tecnologia, Universidade Brasil, Rua Carolina da Fonseca, 584, Bairro Itaquera, São Paulo, 08230-030, Brazil. 2. Centro Universitário Uninovafapi, Rua Vitorino Orthiges Fernandes, n 6123, Bairro Uruguai, Teresina, Piauí, 64073-505, Brazil. 3. Departamento de Medicina Especializada, Universidade Federal do Piauí, Teresina, Piauí, 64049-550, Brazil. 4. Hospital Universitário de Teresina, Campus Universitário Ministro Petrônio Portela, SG 07, s/n - Ininga, Teresina, Piauí, 64049-550, Brazil. 5. Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA. 6. Instituto de Ciência e Tecnologia, Universidade Brasil, Rua Carolina da Fonseca, 584, Bairro Itaquera, São Paulo, 08230-030, Brazil. aolobo@pq.cnpq.br. 7. Programa de Pós-Graduação em Ciência e Engenharia dos Materiais, Universidade Federal do Piauí, Campus Universitário Ministro Petrônio Portella, Bairro Ininga, Teresina, Piauí, 64049-550, Brazil. aolobo@pq.cnpq.br. 8. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, 18-393, Cambridge, MA, 02139, USA. aolobo@pq.cnpq.br.
Abstract
PURPOSE OF REVIEW: To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs). RECENT FINDINGS: The results show that the physical and chemical properties of the nanomaterials are suitable for the fabrication of scaffolds intended for bone regeneration. The in vitro tests suggested a non-toxicity of the GNRs as well as improved biocompatibility and bone mineralization activity. Here, for the first time, we evaluated the potential of GNRs in remodeling and repairing bone defects in osteoporotic animal models in vivo. Interestingly, bone mineralization and the initiation of the remodeling cycle by osteoclasts/osteoblasts were observed after the implantation of GNRs, thus implying healthy bone remodeling when using GNRs. This study, therefore, has opened our perspectives and certainly calls for more attention to the use of carbon nanomaterials for a wide range of osteoporosis applications.
PURPOSE OF REVIEW: To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenicrats treated with graphene nanoribbons (GNRs). RECENT FINDINGS: The results show that the physical and chemical properties of the nanomaterials are suitable for the fabrication of scaffolds intended for bone regeneration. The in vitro tests suggested a non-toxicity of the GNRs as well as improved biocompatibility and bone mineralization activity. Here, for the first time, we evaluated the potential of GNRs in remodeling and repairing bone defects in osteoporotic animal models in vivo. Interestingly, bone mineralization and the initiation of the remodeling cycle by osteoclasts/osteoblasts were observed after the implantation of GNRs, thus implying healthy bone remodeling when using GNRs. This study, therefore, has opened our perspectives and certainly calls for more attention to the use of carbon nanomaterials for a wide range of osteoporosis applications.
Authors: R Ricci; N C S Leite; N S da-Silva; C Pacheco-Soares; R A Canevari; F R Marciano; T J Webster; A O Lobo Journal: Mater Sci Eng C Mater Biol Appl Date: 2017-04-13 Impact factor: 7.328
Authors: Marco Orecchioni; Davide Bedognetti; Francesco Sgarrella; Francesco M Marincola; Alberto Bianco; Lucia Gemma Delogu Journal: J Transl Med Date: 2014-05-21 Impact factor: 5.531
Authors: Leila S S M Magalhães; Danielle B Andrade; Roosevelt D S Bezerra; Alan I S Morais; Francilio C Oliveira; Márcia S Rizzo; Edson C Silva-Filho; Anderson O Lobo Journal: J Funct Biomater Date: 2022-05-04