| Literature DB >> 19284728 |
Nobuyo Narita1, Yasuhiro Kobayashi, Hiroaki Nakamura, Kazuhiro Maeda, Akihiro Ishihara, Toshihide Mizoguchi, Yuki Usui, Kaoru Aoki, Masayuki Simizu, Hiroyuki Kato, Hidehiro Ozawa, Nobuyuki Udagawa, Morinobu Endo, Naoyuki Takahashi, Naoto Saito.
Abstract
Since attention has been paid to the use of multiwalled carbon nanotubes (MWCNTs) as biomaterials in contact with bone, it is critical to understand the reaction of bone cells to MWCNTs. We show that MWCNTs inhibit osteoclastic bone resorption in vivo and that MWCNTs inhibit osteoclastic differentiation and suppressed a transcription factor essential for osteoclastogenesis in vitro. These results suggest that MWCNTs have beneficial effects on bones when they are used as biomaterials.Entities:
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Year: 2009 PMID： 19284728 DOI： 10.1021/nl8030746
Source DB: PubMed Journal: Nano Lett ISSN： 1530-6984 Impact factor: 11.189