| Literature DB >> 30202859 |
Triin Laisk1,2,3, Viktorija Kukuškina2, Duncan Palmer4,5, Samantha Laber6,7, Chia-Yen Chen4,8,9, Teresa Ferreira6, Nilufer Rahmioglu7, Krina Zondervan7,10, Christian Becker10, Jordan W Smoller5,8, Margaret Lippincott11, Andres Salumets1,3,12,13, Ingrid Granne14, Stephanie Seminara11, Benjamin Neale4,8, Reedik Mägi2, Cecilia M Lindgren6,7,15.
Abstract
The normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially controlled by genetic factors, especially in the follicle-stimulating hormone beta-subunit (FSHB) locus. A genome-wide association study meta-analysis of menstrual cycle length in 44 871 women of European ancestry confirmed the previously observed association with the FSHB locus and identified four additional novel signals in, or near, the GNRH1, PGR, NR5A2 and INS-IGF2 genes. These findings not only confirm the role of the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length but also highlight potential novel local regulatory mechanisms, such as those mediated by IGF2.Entities:
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Year: 2018 PMID： 30202859 PMCID： PMC6276838 DOI： 10.1093/hmg/ddy317
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150