Literature DB >> 30199138

Near-Infrared Semiconducting Polymer Brush and pH/GSH-Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor-Specific Phototheranostics.

Zhen Yang1,2,3, Wenpei Fan3, Wei Tang3, Zheyu Shen3, Yunlu Dai3, Jibin Song3, Zhantong Wang3, Yuan Liu3, Lisen Lin3, Lingling Shan3, Yijing Liu3, Orit Jacobson3, Pengfei Rong1,2, Wei Wang1,2, Xiaoyuan Chen3.   

Abstract

Tumor-specific phototheranostics is conducive to realizing precise cancer therapy. Herein, a novel tumor microenvironment (TME)-responsive phototheranostic paradigm based on the combination of semiconducting polymer brushes and polyoxometalate clusters (SPB@POM) is rationally designed. The acidic TME could drive the self-assembly of SPB@POM into bigger aggregates for enhanced tumor retention and accumulation, while the reducing TME could significantly enhance the NIR absorption of SPB@POM for significant improvement of photoacoustic imaging contrast and photothermal therapy efficacy. Therefore, the smart pH/glutathione (GSH)-responsive SPB@POM allows for remarkable phototheranostic enhancement under the unique TME, which has potential for precise tumor-specific phototheranostics with minimal side effects.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  photoacoustic imaging; phototheranostics; photothermal therapy; semiconducting polymers; tumor microenvironment

Mesh：

Substances：

Year:  2018        PMID： 30199138      PMCID： PMC6629039          DOI： 10.1002/anie.201808074

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  20 in total

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10.  pH-responsive perylenediimide nanoparticles for cancer trimodality imaging and photothermal therapy.

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