Sadeq A Quraishi1, Carlos A Camargo2. 1. Vitamin D In Stress (ViDIS) Laboratory, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, 5 Fruit Street, GRJ 402, Boston, MA 02114, USA, squraishi@partners.org. 2. Emergency Medicine Network (EMNet) Coordinating Center, Department of Emergency Medicine, Massachusetts General Hospital, 326 Cambridge St, Suite 410, Boston, MA 02114, ccamargo@partners.org.
Abstract
OBJECTIVE: To review the current literature regarding vitamin D insufficiency and supplementation in major illnesses. DESIGN AND METHODS: We reviewed Pubmed-indexed, English language manuscripts from January, 2003 to June, 2012 using search terms related to vitamin D, all-cause mortality, cardiovascular disease, pulmonary disease, diabetes mellitus, and cancer. OUTCOME MEASURES: Incidence of disease, risk ratios associated with 25-hydroxyvitamin D [25(OH)D] levels, and/or vitamin D supplementation schedules were documented. RESULTS: Although 25(OH)D levels ≥20 ng/mL were often associated with improved health outcomes, evidence suggests that 25(OH)D levels ≥30 ng/mL may confer additional health benefits. CONCLUSIONS: Based on the available evidence, vitamin D supplementation to restore 25(OH)D levels within a range of 30-50 ng/mL is reasonable in order to optimize potential benefits and minimize potential risks. This, of course, should be considered in the context of individual patient needs and co-morbidities.
OBJECTIVE: To review the current literature regarding vitamin Dinsufficiency and supplementation in major illnesses. DESIGN AND METHODS: We reviewed Pubmed-indexed, English language manuscripts from January, 2003 to June, 2012 using search terms related to vitamin D, all-cause mortality, cardiovascular disease, pulmonary disease, diabetes mellitus, and cancer. OUTCOME MEASURES: Incidence of disease, risk ratios associated with 25-hydroxyvitamin D [25(OH)D] levels, and/or vitamin D supplementation schedules were documented. RESULTS: Although 25(OH)D levels ≥20 ng/mL were often associated with improved health outcomes, evidence suggests that 25(OH)D levels ≥30 ng/mL may confer additional health benefits. CONCLUSIONS: Based on the available evidence, vitamin D supplementation to restore 25(OH)D levels within a range of 30-50 ng/mL is reasonable in order to optimize potential benefits and minimize potential risks. This, of course, should be considered in the context of individual patient needs and co-morbidities.
Entities:
Keywords:
25(OH)D; 25-hydroxyvitamin; Vitamin D; chronic illness; general health; restorative medicine
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