BACKGROUND: Low serum level of vitamin D was shown to be associated with cardiovascular diseases as well as the presence of diabetes, dyslipidemia, and hypertension. Vitamin D deficiency is a global problem, and is an Iranian problem as well. To the best of our knowledge, this was the first study on acute myocardial infarction that evaluates the correlation of vitamin D level with inpatients' outcomes, particularly on the early biomarkers of myocardial remodeling. METHODS: In a prospective study, patients with acute ST segment elevation myocardial infarction were included. The patients' 25 (OH) D levels were identified and the associations with clinical characteristics, including early remodeling biomarkers and in-hospital outcomes, were investigated. RESULTS: From the 139 included patients, 80.5% were male. The 25 (OH) deficiency was present in 72.7% of the patients. Hypertension and positive history of cardiovascular drug use were risk factors for the presence of low vitamin D levels (OR = 2.92; CI = 1.34-6.37, P < 0.05) and (OR = 2.36; CI = 1.05-5.29, P < 0.05), respectively. Moreover, a significant positive relationship between the inpatients' survival and the concentration of vitamin D was present (P < 0.001). By performing a multivariate analysis, we found that there was a significant inverse relationship between the level of 25 (OH) D and the level of MMP-9 after 72 h (P = 0.011). CONCLUSION: The results of our study revealed a significant inverse relationship between serum MMP-9 as a biomarker of early remodeling and the level of 25(OH) D in patients after an acute myocardial infarction. Moreover, low level of vitamin D was associated with patients' mortality in this study.
BACKGROUND: Low serum level of vitamin D was shown to be associated with cardiovascular diseases as well as the presence of diabetes, dyslipidemia, and hypertension. Vitamin D deficiency is a global problem, and is an Iranian problem as well. To the best of our knowledge, this was the first study on acute myocardial infarction that evaluates the correlation of vitamin D level with inpatients' outcomes, particularly on the early biomarkers of myocardial remodeling. METHODS: In a prospective study, patients with acute ST segment elevation myocardial infarction were included. The patients' 25 (OH) D levels were identified and the associations with clinical characteristics, including early remodeling biomarkers and in-hospital outcomes, were investigated. RESULTS: From the 139 included patients, 80.5% were male. The 25 (OH) deficiency was present in 72.7% of the patients. Hypertension and positive history of cardiovascular drug use were risk factors for the presence of low vitamin D levels (OR = 2.92; CI = 1.34-6.37, P < 0.05) and (OR = 2.36; CI = 1.05-5.29, P < 0.05), respectively. Moreover, a significant positive relationship between the inpatients' survival and the concentration of vitamin D was present (P < 0.001). By performing a multivariate analysis, we found that there was a significant inverse relationship between the level of 25 (OH) D and the level of MMP-9 after 72 h (P = 0.011). CONCLUSION: The results of our study revealed a significant inverse relationship between serum MMP-9 as a biomarker of early remodeling and the level of 25(OH) D in patients after an acute myocardial infarction. Moreover, low level of vitamin D was associated with patients' mortality in this study.
Authors: Gabriella Rodriguez; Aijing Z Starr; Grazyna Z Czernuszewicz; Amit Manhas; Ahmad Alhariri; James T Willerson; Craig J Reist; Karen Pieper; Kenneth W Mahaffey; Ali J Marian; Neal S Kleiman Journal: Eur J Clin Invest Date: 2011-05-25 Impact factor: 4.686
Authors: Jared P Reis; Denise von Mühlen; Donna Kritz-Silverstein; Deborah L Wingard; Elizabeth Barrett-Connor Journal: Diabetes Care Date: 2007-03-10 Impact factor: 19.112
Authors: Annamari Kilkkinen; Paul Knekt; Antti Aro; Harri Rissanen; Jukka Marniemi; Markku Heliövaara; Olli Impivaara; Antti Reunanen Journal: Am J Epidemiol Date: 2009-09-17 Impact factor: 4.897
Authors: Johan Sundström; Jane C Evans; Emelia J Benjamin; Daniel Levy; Martin G Larson; Douglas B Sawyer; Deborah A Siwik; Wilson S Colucci; Patrice Sutherland; Peter W F Wilson; Ramachandran S Vasan Journal: Circulation Date: 2004-06-01 Impact factor: 29.690
Authors: Andrea Z LaCroix; Jane Kotchen; Garnet Anderson; Robert Brzyski; Jane A Cauley; Steven R Cummings; Margery Gass; Karen C Johnson; Marcia Ko; Joseph Larson; JoAnn E Manson; Marcia L Stefanick; Jean Wactawski-Wende Journal: J Gerontol A Biol Sci Med Sci Date: 2009-02-16 Impact factor: 6.053
Authors: Michael S K Wong; R Delansorne; Ricky Y K Man; Paul M Vanhoutte Journal: Am J Physiol Heart Circ Physiol Date: 2008-05-16 Impact factor: 4.733
Authors: Christian A Gleissner; Christian Erbel; Julia Haeussler; Mohammadreza Akhavanpoor; Gabriele Domschke; Fabian Linden; Andreas O Doesch; Göran Conradson; Sebastian J Buss; Nina P Hofmann; Gitsios Gitsioudis; Hugo A Katus; Grigorios Korosoglou Journal: Clin Res Cardiol Date: 2014-08-08 Impact factor: 5.460
Authors: Katharina Kienreich; Andreas Tomaschitz; Nicolas Verheyen; Thomas Pieber; Martin Gaksch; Martin R Grübler; Stefan Pilz Journal: Nutrients Date: 2013-07-31 Impact factor: 5.717