Nikolaos P Polyzos1, Panagiotis Drakopoulos2, Jose Parra3, Antonio Pellicer4, Samuel Santos-Ribeiro5, Herman Tournaye6, Ernesto Bosch7, Juan Garcia-Velasco8. 1. Department of Reproductive Medicine, Dexeus University Hospital, Barcelona, Spain; Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Brussels, Belgium; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark. Electronic address: nikpol@dexeus.com. 2. Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Brussels, Belgium; Center for Reproductive Medicine, UZ Brussel, Brussels, Belgium; Department of Reproductive Medicine, University of Liège, Liège, Belgium. 3. CleanicData, Leuven, Belgium. 4. Instituto Valenciano de Infertilidad, IVI-RMA Roma, Rome, Italy. 5. Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Brussels, Belgium; Center for Reproductive Medicine, UZ Brussel, Brussels, Belgium; Department of Obstetrics, Gynaecology and Reproductive Medicine, Santa Maria University Hospital, Lisbon, Portugal. 6. Faculty of Medicine and Pharmacy, Department of Surgical and Clinical Science, Vrije Universiteit Brussel, Brussels, Belgium; Center for Reproductive Medicine, UZ Brussel, Brussels, Belgium. 7. Instituto Valenciano de Infertilidad, IVI-RMA Valencia, Valencia, Spain. 8. Instituto Valenciano de Infertilidad, IVI-RMA Madrid, Madrid, Spain; Rey Juan Carlos University, Madrid, Spain.
Abstract
OBJECTIVE: To evaluate the association between the number of oocytes retrieved and cumulative live birth rates. DESIGN: Retrospective multicenter analysis using individual patient data. SETTING: Tertiary referral hospitals. PATIENT(S): In total, 14,469 patients were analyzed. The study included the first cycle of patients stimulated for IVF/intracytoplasmic sperm injection (ICSI) from 2009 to 2014. All patients included in the analysis had either delivered a baby or had used all their embryos after their first stimulated cycle. All patients had vitrification as cryopreservation method. All women were followed up for at least 2 years. INTERVENTION(S): Ovarian stimulation with GnRH antagonist protocol for IVF/ICSI. MAIN OUTCOME MEASURE(S): The primary outcome was the cumulative live birth rate defined as the delivery of at least one live-born infant (>24 weeks of gestation) in the fresh or in the subsequent frozen-thawed cycles in relation to the number of oocytes retrieved. Only the first delivery was considered in the analysis. The secondary outcome was live birth after the fresh IVF/ICSI cycle only. RESULT(S): Cumulative live birth rates steadily increased with the number of oocytes, reaching 70% when ≥25 oocytes were retrieved. Interestingly, no plateau in cumulative live birth rates was observed, but a moderate increase of 5.1% on average was detected beyond 27 oocytes. Regarding the fresh cycle outcome, live birth probability increased up to seven oocytes retrieved and remained relatively unchanged (increase or decrease of ≤5%) between seven and 20 oocytes retrieved. However, a drop in fresh live birth rates was identified thereafter, which could be attributed to the progressive increase in "freeze-all" cycle rate with the number of oocytes retrieved, exceeding 20% in patients with >20 oocytes retrieved. CONCLUSION(S): This is the largest multicenter study evaluating for the first time the impact of ovarian response on cumulative live birth rate. The significant progressive increase of cumulative live birth rate with the number of oocytes in our study suggests that ovarian stimulation may not have a detrimental effect on oocyte/embryo quality in good-prognosis women less than 40 year old. Nevertheless, although very high ovarian response may further increase cumulative live birth rates, ovarian stimulation should be rational and avoid extreme response in terms of oocytes retrieved to preserve patients' convenience and safety and avoid ovarian hyperstimulation syndrome or other iatrogenic complications.
OBJECTIVE: To evaluate the association between the number of oocytes retrieved and cumulative live birth rates. DESIGN: Retrospective multicenter analysis using individual patient data. SETTING: Tertiary referral hospitals. PATIENT(S): In total, 14,469 patients were analyzed. The study included the first cycle of patients stimulated for IVF/intracytoplasmic sperm injection (ICSI) from 2009 to 2014. All patients included in the analysis had either delivered a baby or had used all their embryos after their first stimulated cycle. All patients had vitrification as cryopreservation method. All women were followed up for at least 2 years. INTERVENTION(S): Ovarian stimulation with GnRH antagonist protocol for IVF/ICSI. MAIN OUTCOME MEASURE(S): The primary outcome was the cumulative live birth rate defined as the delivery of at least one live-born infant (>24 weeks of gestation) in the fresh or in the subsequent frozen-thawed cycles in relation to the number of oocytes retrieved. Only the first delivery was considered in the analysis. The secondary outcome was live birth after the fresh IVF/ICSI cycle only. RESULT(S): Cumulative live birth rates steadily increased with the number of oocytes, reaching 70% when ≥25 oocytes were retrieved. Interestingly, no plateau in cumulative live birth rates was observed, but a moderate increase of 5.1% on average was detected beyond 27 oocytes. Regarding the fresh cycle outcome, live birth probability increased up to seven oocytes retrieved and remained relatively unchanged (increase or decrease of ≤5%) between seven and 20 oocytes retrieved. However, a drop in fresh live birth rates was identified thereafter, which could be attributed to the progressive increase in "freeze-all" cycle rate with the number of oocytes retrieved, exceeding 20% in patients with >20 oocytes retrieved. CONCLUSION(S): This is the largest multicenter study evaluating for the first time the impact of ovarian response on cumulative live birth rate. The significant progressive increase of cumulative live birth rate with the number of oocytes in our study suggests that ovarian stimulation may not have a detrimental effect on oocyte/embryo quality in good-prognosis women less than 40 year old. Nevertheless, although very high ovarian response may further increase cumulative live birth rates, ovarian stimulation should be rational and avoid extreme response in terms of oocytes retrieved to preserve patients' convenience and safety and avoid ovarian hyperstimulation syndrome or other iatrogenic complications.
Authors: Raoul Orvieto; Christos A Venetis; Human M Fatemi; Thomas D'Hooghe; Robert Fischer; Yulia Koloda; Marcos Horton; Michael Grynberg; Salvatore Longobardi; Sandro C Esteves; Sesh K Sunkara; Yuan Li; Carlo Alviggi Journal: Front Endocrinol (Lausanne) Date: 2021-05-10 Impact factor: 5.555