Literature DB >> 30196839

Variability in PolyIC induced immune response: Implications for preclinical maternal immune activation models.

Milo Careaga1, Sandra L Taylor2, Carolyn Chang3, Alex Chiang1, Katherine M Ku1, Robert F Berman4, Judy A Van de Water5, Melissa D Bauman6.   

Abstract

Maternal infection during pregnancy may increase the risk of offspring neurodevelopmental disorders. The preclinical Polyinosinic-polycytidylic acid (PolyIC) model has become one of the most widely used approaches in maternal immune activation (MIA) research. However, variability in molecular weight may impact the immune activating potential of PolyIC. Nulliparous rats injected with high molecular weight PolyIC exhibit pronounced cytokine response and sickness behavior that was not observed in rats injected low molecular weight PolyIC. Although an essential next step is to extend these studies to pregnant animals, the preliminary results suggest that PolyIC molecular weight is an important experimental design consideration.
Copyright © 2018. Published by Elsevier B.V.

Entities:  

Keywords:  Cytokine; Immune; Maternal immune activation; PolyIC; Polyinosinic-polycytidylic acid; Sickness behavior

Mesh：

Substances：

Year:  2018        PMID： 30196839      PMCID： PMC6782055          DOI： 10.1016/j.jneuroim.2018.06.014

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  72 in total

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Authors:  C Glenn Begley; John P A Ioannidis
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Review 3.  The poly(I:C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery.

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Journal:  Pharmacol Ther       Date:  2015-01-04       Impact factor: 12.310

Review 4.  To poly(I:C) or not to poly(I:C): advancing preclinical schizophrenia research through the use of prenatal immune activation models.

Authors:  Urs Meyer; Joram Feldon
Journal:  Neuropharmacology       Date:  2011-01-14       Impact factor: 5.250

5.  Increased affective ultrasonic communication during fear learning in adult male rats exposed to maternal immune activation.

Authors:  Nicole Yee; Rainer K W Schwarting; Eberhard Fuchs; Markus Wöhr
Journal:  J Psychiatr Res       Date:  2012-06-10       Impact factor: 4.791

Review 6.  In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders.

Authors:  Urs Meyer; Joram Feldon; S Hossein Fatemi
Journal:  Neurosci Biobehav Rev       Date:  2009-05-12       Impact factor: 8.989

7.  Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type.

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8.  The risk for behavioural deficits is determined by the maternal immune response to prenatal immune challenge in a neurodevelopmental model.

Authors:  S Missault; K Van den Eynde; W Vanden Berghe; E Fransen; A Weeren; J P Timmermans; S Kumar-Singh; S Dedeurwaerdere
Journal:  Brain Behav Immun       Date:  2014-06-26       Impact factor: 7.217

9.  The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring.

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  12 in total

1.  Maternal immune activation accelerates puberty initiation and alters mechanical allodynia in male and female C57BL6/J mice.

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Journal:  Dev Psychobiol       Date:  2022-07       Impact factor: 2.531

2.  An Optimized Direct Lysis Gene Expression Microplate Assay and Applications for Disease, Differentiation, and Pharmacological Cell-Based Studies.

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3.  Interleukin 15 modulates the effects of poly I:C maternal immune activation on offspring behaviour.

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5.  Maternal Immune Activation with the Viral Mimetic Poly:IC in Pregnant Rats.

Authors:  Thaísa Meira Sandini; Quentin Greba; Brittney Rose Lins; John George Howland
Journal:  Bio Protoc       Date:  2020-11-20

6.  Maternal Immune Activation during Pregnancy Alters the Behavior Profile of Female Offspring of Sprague Dawley Rats.

Authors:  Brittney R Lins; Wendie N Marks; Nadine K Zabder; Quentin Greba; John G Howland
Journal:  eNeuro       Date:  2019-04-19

7.  Mapping the impact of exposure to maternal immune activation on juvenile Wistar rat brain macro- and microstructure during early post-natal development.

Authors:  Tobias C Wood; Michelle E Edye; Michael K Harte; Joanna C Neill; Eric P Prinssen; Anthony C Vernon
Journal:  Brain Neurosci Adv       Date:  2019-11-04

8.  Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age.

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9.  Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness.

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10.  A Rat Model of Prenatal Zika Virus Infection and Associated Long-Term Outcomes.

Authors:  Morgan L Sherer; Elise A Lemanski; Rita T Patel; Shannon R Wheeler; Mark S Parcells; Jaclyn M Schwarz
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