Literature DB >> 30194559

Microbe-mediate transformation of echinocystic acid by whole cells of filamentous fungus Cunninghamella blakesleana CGMCC 3.910.

Shaobin Fu1,2, Xu Feng3,4, Di-An Sun5.   

Abstract

Structural modification of echinocystic acid (EA), a pentacyclic triterpenoid with wide spread biological activities was investigated by microbial transformation. Microbe-mediate transformation of EA was carried out by filamentous fungus Cunninghamella blakesleana CGMCC 3.910. Four metabolites 3β, 7β, 16α-trihydroxy-olean-12-en-28-oic acid (EA-2); 3β, 7β, 16β,19β-tetrahydroxy-olean-12-en-28-oic acid (EA-3); 3β, 7β, 16α, 21β-tetrahydroxy-olean-12-en-28-oic acid (EA-4); 3β, 7β, 16α-trihydroxy-olean-11, 13(18)-dien-28-oic acid (EA-5) were produced. Structures of transformed products were elucidated by 1D and 2D NMR and HR-MS data. EA-3 and EA-4 were new compounds.

Entities:  

Keywords:  Biocatalysis; Echinocystic acid; Fungus; Pentacyclic triterpenoids

Mesh：

Substances：

Year:  2018        PMID： 30194559     DOI： 10.1007/s11033-018-4357-7

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  21 in total

1.  New derivatives of ursolic acid through the biotransformation by Bacillus megaterium CGMCC 1.1741 as inhibitors on nitric oxide production.

Authors:  Chao Zhang; Shao-Hua Xu; Bai-Ling Ma; Wei-Wei Wang; Bo-Yang Yu; Jian Zhang
Journal:  Bioorg Med Chem Lett       Date:  2017-03-27       Impact factor: 2.823

2.  Two Furanharzianones with 4/7/5/6/5 Ring System from Microbial Transformation of Harzianone.

Authors:  Min Zhang; Jimei Liu; Ridao Chen; Jinlian Zhao; Kebo Xie; Dawei Chen; Keping Feng; Jungui Dai
Journal:  Org Lett       Date:  2017-02-20       Impact factor: 6.005

3.  Bio-assay guided isolation of alpha-glucosidase inhibitory constituents from Eclipta alba.

Authors:  Deepak Kumar; Raghuvir H Gaonkar; Rina Ghosh; Bikas C Pal
Journal:  Nat Prod Commun       Date:  2012-08       Impact factor: 0.986

4.  The triterpene echinocystic acid and its 3-O-glucoside derivative are revealed as potent and selective glucocorticoid receptor agonists.

Authors:  Demetra Georgatza; Vyron A Gorgogietas; Paraskevi Kylindri; Maria Ch Charalambous; Kalliope K Papadopoulou; Joseph M Hayes; Anna-Maria G Psarra
Journal:  Int J Biochem Cell Biol       Date:  2016-08-31       Impact factor: 5.085

5.  Echinocystic acid induces apoptosis in HL-60 cells through mitochondria-mediated death pathway.

Authors:  Xuhui Tong; Shigang Lin; Makoto Fujii; De-Xing Hou
Journal:  Cancer Lett       Date:  2004-08-20       Impact factor: 8.679

6.  Molecular mechanisms of echinocystic acid-induced apoptosis in HepG2 cells.

Authors:  Xuhui Tong; Shigang Lin; Makoto Fujii; De-Xing Hou
Journal:  Biochem Biophys Res Commun       Date:  2004-08-27       Impact factor: 3.575

Review 7.  A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents.

Authors:  I Baglin; A-C Mitaine-Offer; M Nour; K Tan; C Cavé; M-A Lacaille-Dubois
Journal:  Mini Rev Med Chem       Date:  2003-09       Impact factor: 3.862

8.  Microbial transformation of the anti-diabetic agent corosolic acid.

Authors:  Xu Feng; Dai-Ping Li; Ze-Sheng Zhang; Zhi-Yong Chu; Jie Luan
Journal:  Nat Prod Res       Date:  2014-09-05       Impact factor: 2.861

9.  Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NF-κB and MAPK pathways.

Authors:  Eun-Ha Joh; Wan Gu; Dong-Hyun Kim
Journal:  Biochem Pharmacol       Date:  2012-05-04       Impact factor: 5.858

10.  The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens.

Authors:  Brandon J H Banaschewski; Brandon Baer; Christina Arsenault; Teah Jazey; Edwin J A Veldhuizen; Johan Delport; Tracey Gooyers; James F Lewis; Henk P Haagsman; Ruud A W Veldhuizen; Cory Yamashita
Journal:  Sci Rep       Date:  2017-11-14       Impact factor: 4.379
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