Literature DB >> 3019233

Synergy between RU 28965 (roxithromycin) and human neutrophils for bactericidal activity in vitro.

M T Labro, N Amit, C Babin-Chevaye, J Hakim.   

Abstract

The in vitro effects of RU 28965 (roxithromycin), a new semisynthetic macrolide, on human neutrophil activity were compared with those of erythromycin. RU 28965, at a concentration as low as 0.1 microgram/ml, significantly enhanced the phagocytosis and killing of Staphylococcus aureus by neutrophils. Erythromycin displayed a less stimulating effect in a dose-dependent manner. Phagocytosis of Klebsiella pneumoniae was also increased after incubation of neutrophils with RU 28965, but killing was not altered. Neutrophil chemotaxis, myeloperoxidase activity, and O2 consumption were unchanged in the presence of RU 28965.

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Year:  1986        PMID： 3019233      PMCID： PMC176451          DOI： 10.1128/AAC.30.1.137

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  34 in total

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Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

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Authors:  E L Westerman; T W Williams; N Moreland
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

5.  [Subinhibitory concentrations of antibiotics. Effects on morphology and growth (author's transl)].

Authors:  V Lorian
Journal:  Pathol Biol (Paris)       Date:  1977-05

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Authors:  D Tremblay; A Bryskier; M Vuckovic; A Stockis; C Manuel
Journal:  Pathol Biol (Paris)       Date:  1985-06

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Authors:  B Kvarstein
Journal:  Scand J Clin Lab Invest       Date:  1970-06       Impact factor: 1.713

8.  The effect of antimicrobial agents on leukocyte chemotaxis.

Authors:  N B Esterly; N L Furey; L E Flanagan
Journal:  J Invest Dermatol       Date:  1978-01       Impact factor: 8.551

9.  A rapid micro method for the simultaneous determination of phagocytic-microbiocidal activity of human peripheral blood leukocytes in vitro.

Authors:  D L Smith; F Rommel
Journal:  J Immunol Methods       Date:  1977       Impact factor: 2.303

10.  Effect of antibiotics of chemotaxis of human leukocytes.

Authors:  A Forsgren; D Schmeling
Journal:  Antimicrob Agents Chemother       Date:  1977-04       Impact factor: 5.191
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  13 in total

1.  Effect of monodesethyl amodiaquine on human polymorphonuclear neutrophil functions in vitro.

Authors:  M T Labro; J el Benna
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

Review 2.  Effects of anti-infectious agents on polymorphonuclear neutrophils.

Authors:  M T Labro; J el Benna
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-02       Impact factor: 3.267

3.  Unpredictable influence of human serum on antimicrobial activity of erythromycin and three oxime ether macrolides.

Authors:  R N Jones; A L Barry
Journal:  Eur J Clin Microbiol       Date:  1987-02       Impact factor: 3.267

4.  Effects of amodiaquine, chloroquine, and mefloquine on human polymorphonuclear neutrophil function in vitro.

Authors:  M T Labro; C Babin-Chevaye
Journal:  Antimicrob Agents Chemother       Date:  1988-08       Impact factor: 5.191

5.  In vitro effects of antimicrobial agents on Mycobacterium leprae in mouse peritoneal macrophages.

Authors:  N Ramasesh; J L Krahenbuhl; R C Hastings
Journal:  Antimicrob Agents Chemother       Date:  1989-05       Impact factor: 5.191

6.  Quinine uptake by human polymorphonuclear neutrophils.

Authors:  J el Benna; C Pasquier; M T Labro
Journal:  Antimicrob Agents Chemother       Date:  1991-07       Impact factor: 5.191

Review 7.  Clarithromycin clinical pharmacokinetics.

Authors:  F Fraschini; F Scaglione; G Demartini
Journal:  Clin Pharmacokinet       Date:  1993-09       Impact factor: 6.447

8.  In vitro and in vivo intraleukocytic accumulation of azithromycin (CP-62, 993) and its influence on ex vivo leukocyte chemiluminescence.

Authors:  M Bonnet; P Van der Auwera
Journal:  Antimicrob Agents Chemother       Date:  1992-06       Impact factor: 5.191

9.  Comparative activity of macrolides against Toxoplasma gondii demonstrating utility of an in vitro microassay.

Authors:  S Chamberland; H A Kirst; W L Current
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

10.  Effect of roxithromycin on acute toxoplasmosis in mice.

Authors:  H R Chang; J C Pechere
Journal:  Antimicrob Agents Chemother       Date:  1987-07       Impact factor: 5.191
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