Literature DB >> 3018274

Baclofen overdose with cardiac conduction abnormalities: case report and review of the literature.

S Nugent, M D Katz, T E Little.   

Abstract

Cardiac conduction abnormalities and hypertension developed in a patient who ingested approximately 500 mg of baclofen (Lioresal). The patient also exhibited the more common features of baclofen overdose including coma, respiratory depression, hypotonia, and hyporeflexia. A review of the literature and a discussion of the interesting manifestations and treatment of baclofen overdose are included.

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Year:  1986        PMID: 3018274     DOI: 10.3109/15563658608992596

Source DB:  PubMed          Journal:  J Toxicol Clin Toxicol        ISSN: 0731-3810


  8 in total

1.  Baclofen intoxication: a "fun drug" causing deep coma and nonconvulsive status epilepticus--a case report and review of the literature.

Authors:  Guido F Weißhaar; Marc Hoemberg; Katja Bender; Ursula Bangen; Peter Herkenrath; Frank Eifinger; Markus Rothschild; Bernhard Roth; André Oberthuer
Journal:  Eur J Pediatr       Date:  2012-06-23       Impact factor: 3.183

2.  Baclofen overdose mimicking anoxic encephalopathy: a case report and review of the literature.

Authors:  John J Miller
Journal:  Ther Adv Drug Saf       Date:  2017-02-01

3.  FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment-a pharmacokinetic-pharmacodynamic study.

Authors:  L M Paterson; D Barker; S Cro; P Mozgunov; R Phillips; C Smith; L Nahar; S Paterson; A R Lingford-Hughes
Journal:  Trials       Date:  2022-10-18       Impact factor: 2.728

4.  Baclofen intoxication after accidental ingestion in a 3-year-old child.

Authors:  Nagesh Dasarwar; Preeti Shanbag; Nilesh Kumbhare
Journal:  Indian J Pharmacol       Date:  2009-04       Impact factor: 1.200

Review 5.  A benefit-risk assessment of baclofen in severe spinal spasticity.

Authors:  Alessandro Dario; Giustino Tomei
Journal:  Drug Saf       Date:  2004       Impact factor: 5.606

6.  Coma With Absent Brainstem Reflexes and a Burst Suppression on EEG Secondary to Baclofen Toxicity.

Authors:  Sahar Farhat; Tarek El Halabi; Achraf Makki; Samir F Atweh; Wassim Nasreddine; Ahmad Beydoun
Journal:  Front Neurol       Date:  2020-05-13       Impact factor: 4.003

7.  Burst Suppression Electroencephalography (EEG) Pattern with Coma and Loss of Brain Stem Reflexes Following a Baclofen Overdose with Subsequent Full Recovery.

Authors:  Jeffrey D McGowan; David P Betten
Journal:  Am J Case Rep       Date:  2022-03-31

Review 8.  Baclofen therapeutics, toxicity, and withdrawal: A narrative review.

Authors:  Jia W Romito; Emily R Turner; John A Rosener; Landon Coldiron; Ashutosh Udipi; Linsey Nohrn; Jacob Tausiani; Bryan T Romito
Journal:  SAGE Open Med       Date:  2021-06-03
  8 in total

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