| Literature DB >> 30179857 |
Djalma M de Oliveira1, Cristiane B Pereira2, Graziele Mendes2, Jochen Junker3, Markus Kolloff4, Luiz H Rosa2, Carlos A Rosa2, Tânia M A Alves4, Carlos L Zani4, Susana Johann2, Betania B Cota5.
Abstract
The endophytic fungus Mycosphaerella sp. (UFMGCB2032) was isolated from the healthy leaves of Eugenia bimarginata, a plant from the Brazilian savanna. Two novel usnic acid derivatives, mycousfuranine (1) and mycousnicdiol (2), were isolated from the ethyl acetate extract, and their structure was elucidated by NMR and MS analyses. Compounds 1 and 2 exhibited moderate antifungal activities against Cryptococcus neoformans and Cryptococcus gattii, each with minimum inhibitory concentration values of 50.0 μg/mL and 250.0 μg/mL, respectively.Entities:
Keywords: Cryptococcus sp.; Eugenia bimarginata; Mycosphaerella sp.; endophytic fungi; usnic acid derivatives
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Year: 2018 PMID： 30179857 DOI： 10.1515/znc-2017-0162
Source DB: PubMed Journal: Z Naturforsch C J Biosci ISSN： 0341-0382