Katrin Hefler-Frischmuth1, Christoph Grimm2, Lisa Gensthaler2, Elisabeth Reiser2, Richard Schwameis2, Lukas A Hefler3,4. 1. Department of Internal Medicine I, Ordensklinikum Linz GmbH Barmherzige Schwestern, Seilerstätte 4, 4010, Linz, Austria. k_hefler@yahoo.com. 2. Department of General Gynecology and Gynecologic Oncology, Gynecologic Cancer Unit, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 3. Department of Gynecology, Ordensklinikum Linz GmbH Barmherzige Schwestern, Linz, Austria. 4. Karl Landsteiner Institute of Gynecologic Surgery and Oncology, Linz, Austria.
Abstract
BACKGROUND: Preoperative hyponatremia and thrombocytosis are associated with perioperative morbidity in patients with epithelial ovarian cancer (EOC). The aim of the present study was to evaluate preoperative hyponatremia and thrombocytosis as prognostic parameters in patients with EOC. METHODS: In a retrospective cohort study, serum levels of sodium and thrombocyte counts were evaluated in 498 patients with EOC. Data were extracted from the prospectively maintained database. Results were correlated with clinicopathological parameters and patient survival. RESULTS: Mean (standard deviation) overall pretherapeutic serum sodium levels and thrombocyte counts in patients with EOC were 138.8 (2.9) mmol/l and 340.1 (122.6) × 103/µl, respectively. Hyponatremia (serum sodium levels ≤ 134 mmol/l) was found in 33 (6.7%) patients and thrombocytosis (thrombocytes ≥ 450/µl) in 88 (17.7%) patients. Serum sodium levels were associated with the presence or absence of residual tumor tissue after primary surgery. Thrombocyte counts were associated with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) tumor stage, presence/absence of residual tumor, histological grade and histological type. Patients with thrombocytosis presented with advanced tumor stage, a higher rate of postoperative residual tumor mass, higher tumor grade, and a higher rate of serous ovarian cancer. In a multivariate logistic regression analysis, only the established clinicopathological parameters but not serum sodium and thrombocyte count were independent predictors of patient overall survival. CONCLUSION: Preoperative hyponatremia and thrombocytosis are not useful as additional independent prognostic parameters in patients with EOC.
BACKGROUND: Preoperative hyponatremia and thrombocytosis are associated with perioperative morbidity in patients with epithelial ovarian cancer (EOC). The aim of the present study was to evaluate preoperative hyponatremia and thrombocytosis as prognostic parameters in patients with EOC. METHODS: In a retrospective cohort study, serum levels of sodium and thrombocyte counts were evaluated in 498 patients with EOC. Data were extracted from the prospectively maintained database. Results were correlated with clinicopathological parameters and patient survival. RESULTS: Mean (standard deviation) overall pretherapeutic serum sodium levels and thrombocyte counts in patients with EOC were 138.8 (2.9) mmol/l and 340.1 (122.6) × 103/µl, respectively. Hyponatremia (serum sodium levels ≤ 134 mmol/l) was found in 33 (6.7%) patients and thrombocytosis (thrombocytes ≥ 450/µl) in 88 (17.7%) patients. Serum sodium levels were associated with the presence or absence of residual tumor tissue after primary surgery. Thrombocyte counts were associated with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) tumor stage, presence/absence of residual tumor, histological grade and histological type. Patients with thrombocytosis presented with advanced tumor stage, a higher rate of postoperative residual tumor mass, higher tumor grade, and a higher rate of serous ovarian cancer. In a multivariate logistic regression analysis, only the established clinicopathological parameters but not serum sodium and thrombocyte count were independent predictors of patient overall survival. CONCLUSION: Preoperative hyponatremia and thrombocytosis are not useful as additional independent prognostic parameters in patients with EOC.
Authors: Alberto A Mendivil; Mark A Rettenmaier; Lisa N Abaid; John V Brown; Kristina M Mori; Bram H Goldstein Journal: Arch Gynecol Obstet Date: 2016-11-10 Impact factor: 2.344
Authors: Rhiannon Coulson; Seng H Liew; Angela A Connelly; Nicholas S Yee; Siddhartha Deb; Beena Kumar; Ana C Vargas; Sandra A O'Toole; Adam C Parslow; Ashleigh Poh; Tracy Putoczki; Riley J Morrow; Mariah Alorro; Kyren A Lazarus; Evie F W Yeap; Kelly L Walton; Craig A Harrison; Natalie J Hannan; Amee J George; Colin D Clyne; Matthias Ernst; Andrew M Allen; Ashwini L Chand Journal: Oncotarget Date: 2017-03-21
Authors: Gabriella D Cozzi; Jacob M Samuel; Jason T Fromal; Spencer Keene; Marta A Crispens; Dineo Khabele; Alicia Beeghly-Fadiel Journal: BMC Cancer Date: 2016-08-08 Impact factor: 4.430
Authors: Nienke Zwakman; Rafli van de Laar; Toon Van Gorp; Petra L M Zusterzeel; Marc P M L Snijders; Isabel Ferreira; Leon F A G Massuger; Roy F P M Kruitwagen Journal: J Gynecol Oncol Date: 2016-09-12 Impact factor: 4.401