Kanako Nakazawa1, Takamasa Noda2, Kanako Ichikura3, Tomoko Okamoto4, Yuji Takahashi5, Takashi Yamamura6, Kazuyuki Nakagome7. 1. Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Japan; Department of Neuropsychiatry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan. 2. Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Japan; Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Japan; Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Japan. Electronic address: t-noda@ncnp.go.jp. 3. Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan; Department of Health Science, School of Allied Health Sciences, Kitasato University, Japan. 4. Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Japan; Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Japan. 5. Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Japan. 6. Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Japan; Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Japan. 7. National Institute of Mental Health, National Center of Neurology and Psychiatry (NCNP), Japan.
Abstract
BACKGROUND: Depression and anxiety are common in multiple sclerosis (MS) and recently, studies on these symptoms in neuromyelitis optica spectrum disorder (NMOSD) are increasing. Previous studies suggest that these symptoms have negative effects on the quality of life. Resilience has garnered more interest as one of the protective factors that works to prevent psychiatric symptoms in past decades. There exist a few studies, however, regarding the effects of resilience on these psychiatric symptoms in MS/NMOSD. OBJECTIVE: The aim of this study was to clarify the relationships between resilience, psychiatric symptoms, and QOL in patients with MS/NMOSD. METHOD: Seventy-seven patients with MS/NMOSD participated in this study. They completed several questionnaires (Beck Depression Inventory-Second edition, Hospital Anxiety and Depression Scale, the Japanese version of the Resilience scale [RS], and Japanese version of Multiple Sclerosis Quality of Life-54). We also collected demographic and clinical data including age, sex, physical disability level (measured with the Expanded Disability Status Scale [EDSS]), and disease duration of the participants. RESULTS: The EDSS scores showed significant negative correlations with QOL, unlike disease duration, which did not correlate with either the psychiatric symptoms or QOL. Additionally, there was no significant correlation between RS scores and EDSS scores or disease duration. We also found that resilience showed a significant negative correlation with psychiatric symptoms, and positive correlation with QOL. CONCLUSION: These results suggest that resilience may serve to prevent or reduce depression/anxiety symptoms and maintain the QOL regardless of the physical disability level.
BACKGROUND:Depression and anxiety are common in multiple sclerosis (MS) and recently, studies on these symptoms in neuromyelitis optica spectrum disorder (NMOSD) are increasing. Previous studies suggest that these symptoms have negative effects on the quality of life. Resilience has garnered more interest as one of the protective factors that works to prevent psychiatric symptoms in past decades. There exist a few studies, however, regarding the effects of resilience on these psychiatric symptoms in MS/NMOSD. OBJECTIVE: The aim of this study was to clarify the relationships between resilience, psychiatric symptoms, and QOL in patients with MS/NMOSD. METHOD: Seventy-seven patients with MS/NMOSD participated in this study. They completed several questionnaires (Beck Depression Inventory-Second edition, Hospital Anxiety and Depression Scale, the Japanese version of the Resilience scale [RS], and Japanese version of Multiple Sclerosis Quality of Life-54). We also collected demographic and clinical data including age, sex, physical disability level (measured with the Expanded Disability Status Scale [EDSS]), and disease duration of the participants. RESULTS: The EDSS scores showed significant negative correlations with QOL, unlike disease duration, which did not correlate with either the psychiatric symptoms or QOL. Additionally, there was no significant correlation between RS scores and EDSS scores or disease duration. We also found that resilience showed a significant negative correlation with psychiatric symptoms, and positive correlation with QOL. CONCLUSION: These results suggest that resilience may serve to prevent or reduce depression/anxiety symptoms and maintain the QOL regardless of the physical disability level.
Authors: Jose E Meca-Lallana; Daniel Prefasi; Francisco Pérez-Miralles; Lucía Forero; María Sepúlveda; Carmen Calles; María L Martínez-Ginés; Inés González-Suárez; Sabas Boyero; Lucía Romero-Pinel; Ángel P Sempere; Virginia Meca-Lallana; Luis Querol; Lucienne Costa-Frossard; Hugo de Castro-Trapiello; Neus Canal; Jorge Maurino Journal: Patient Prefer Adherence Date: 2021-04-12 Impact factor: 2.711