Fernando Casas-Méndez1,2, Alicia Sánchez-de-la-Torre1,2, Joan Valls3, Manuel Sánchez-de-la-Torre1,2, Jorge Abad4, Joaquin Duran-Cantolla2,5, Valentin Cabriada6, Juan Fernando Masa2,7, Joaquin Teran2,8, Gerard Castella3, Fernando Worner9, Ferran Barbé1,2. 1. Respiratory Department, Hospital Universitari Arnau de Vilanova and Santa Maria. Universitat de Lleida, Group of Translational Research in Respiratory Medicine - IRB Lleida, Catalonia, Spain. 2. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. 3. Biostatistics and Epidemiology Unit, IRB Lleida, Catalonia, Spain. 4. Respiratory Department, Hospital Universitari Germans Trias I Pujol, Badalona, Catalonia, Spain. 5. Bio-Araba Research Institute, Hospital Universitario de Araba, Department of Medicine of Basque Country University, Vitoria-Gasteiz, Spain. 6. Respiratory Department, Hospital Universitario Cruces, Bilbao, Spain. 7. Respiratory Department, Hospital San Pedro de Alcantara, Cáceres, Spain. 8. Respiratory Department, Hospital Universitario de Burgos, Burgos, Spain. 9. Cardiology Department, Hospital Universitari Arnau de Vilanova, IRB Lleida, Universitat de Lleida, Catalonia, Spain.
Abstract
BACKGROUND: Previous population-based studies have suggested that lung function impairment (LFI) could be associated with an increase in the mortality of cardiovascular events. METHODS: We evaluated the association between LFI and the severity and short-term prognosis of acute coronary syndrome (ACS). LFI was established through presence of a forced expiratory volume in one second (FEV1) and/or a forced vital capacity (FVC) less than 80% of predicted. RESULTS: Seventy-one LFI subjects (61.45±10.70 years, 83.10% males) and 247 non-LFI subjects (58.98±11.18 years, 80.57% males) with ACS were included. Subjects with LFI exhibited a higher prevalence of systemic hypertension (57.75% vs. 40.89%, P=0.02) and tobacco exposure (28.50±26.67 vs. 18.21±19.83 pack-years, P=0.007). No significant differences between groups were found regarding the severity of ACS (ejection fraction, Killip class, number of affected vessels, and peak plasma troponin). However, in comparison to non-LFI subjects, a significantly shorter length of stay in the coronary care unit (CCU) was observed in the LFI group (1.83±1.10 vs. 2.24±1.21 days, P=0.01) and this was even shorter in subjects with obstructive LFI (1.62±1.17 days, P=0.009). When considering obstructive sleep apnea (OSA), an interaction with length of stay was found, revealing that OSA subjects with obstructive LFI had the shortest length of stay in the CCU (0.60±0.89 days, P=0.05) also in comparison to non-LFI. CONCLUSIONS: This study indicates a possible association between LFI and a shorter length of stay in the CCU but does not show a significant association with ACS severity.
BACKGROUND: Previous population-based studies have suggested that lung function impairment (LFI) could be associated with an increase in the mortality of cardiovascular events. METHODS: We evaluated the association between LFI and the severity and short-term prognosis of acute coronary syndrome (ACS). LFI was established through presence of a forced expiratory volume in one second (FEV1) and/or a forced vital capacity (FVC) less than 80% of predicted. RESULTS: Seventy-one LFI subjects (61.45±10.70 years, 83.10% males) and 247 non-LFI subjects (58.98±11.18 years, 80.57% males) with ACS were included. Subjects with LFI exhibited a higher prevalence of systemic hypertension (57.75% vs. 40.89%, P=0.02) and tobacco exposure (28.50±26.67 vs. 18.21±19.83 pack-years, P=0.007). No significant differences between groups were found regarding the severity of ACS (ejection fraction, Killip class, number of affected vessels, and peak plasma troponin). However, in comparison to non-LFI subjects, a significantly shorter length of stay in the coronary care unit (CCU) was observed in the LFI group (1.83±1.10 vs. 2.24±1.21 days, P=0.01) and this was even shorter in subjects with obstructive LFI (1.62±1.17 days, P=0.009). When considering obstructive sleep apnea (OSA), an interaction with length of stay was found, revealing that OSA subjects with obstructive LFI had the shortest length of stay in the CCU (0.60±0.89 days, P=0.05) also in comparison to non-LFI. CONCLUSIONS: This study indicates a possible association between LFI and a shorter length of stay in the CCU but does not show a significant association with ACS severity.
Authors: J Roca; F Burgos; J Sunyer; M Saez; S Chinn; J M Antó; R Rodríguez-Roisin; P H Quanjer; D Nowak; P Burney Journal: Eur Respir J Date: 1998-06 Impact factor: 16.671
Authors: Maria Sabater-Lleal; Anders Mälarstig; Lasse Folkersen; María Soler Artigas; Damiano Baldassarre; Maryam Kavousi; Peter Almgren; Fabrizio Veglia; Guy Brusselle; Albert Hofman; Gunnar Engström; Oscar H Franco; Olle Melander; Gabrielle Paulsson-Berne; Hugh Watkins; Per Eriksson; Steve E Humphries; Elena Tremoli; Ulf de Faire; Martin D Tobin; Anders Hamsten Journal: PLoS One Date: 2014-08-05 Impact factor: 3.240