Kazuhiro Ueda1, Junichi Murakami1, Toshiki Tanaka1, Masataro Hayashi2, Kazunori Okabe2, Kimikazu Hamano1. 1. Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan. 2. Division of Thoracic Surgery, National Hospital Organization Yamaguchi-Ube Medical Center, Yamaguchi, Japan.
Abstract
BACKGROUND: Although whole lung computed tomography (CT) is included in the routine workup before lung cancer surgery, it is not utilized to assess the preoperative pulmonary function. METHODS: Two hundred ninety patients (development cohort) who underwent lung lobectomy for cancer in our institute and another 100 patients (validation cohort) who subsequently underwent the same operation in a referral hospital were included. The total lung volume (TLV) and emphysematous lung volume (ELV) were obtained by quantitative CT. RESULTS: The TLV was higher in patients with a smoking history than in those without. The ELV to the TLV was higher in elderly patients than in younger patients. The regression equation for forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) were developed using CT-derived variables, together with sex, age, height, and smoking habit, by a multiple regression analysis in the development cohort. The regression equation-based FVC and FEV1 were significantly correlated with the actual FVC and FEV1 in the development cohort, as well as in the validation cohort. The predicted postoperative FEV1 (ppo%FEV1) calculated based on the regression equation was also correlated with the postoperative FEV1 value obtained by the conventional method (R=0.53), and the regression equation-based ppo%FEV1 was a significant predictor of postoperative cardiopulmonary complications (P=0.02). CONCLUSIONS: Whole lung CT can be used to assess the preoperative pulmonary function in patients undergoing lobectomy for cancer. This method may be helpful in preoperative risk assessment, particularly in patients who have difficulty in implementation of spirometry.
BACKGROUND: Although whole lung computed tomography (CT) is included in the routine workup before lung cancer surgery, it is not utilized to assess the preoperative pulmonary function. METHODS: Two hundred ninety patients (development cohort) who underwent lung lobectomy for cancer in our institute and another 100 patients (validation cohort) who subsequently underwent the same operation in a referral hospital were included. The total lung volume (TLV) and emphysematous lung volume (ELV) were obtained by quantitative CT. RESULTS: The TLV was higher in patients with a smoking history than in those without. The ELV to the TLV was higher in elderly patients than in younger patients. The regression equation for forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) were developed using CT-derived variables, together with sex, age, height, and smoking habit, by a multiple regression analysis in the development cohort. The regression equation-based FVC and FEV1 were significantly correlated with the actual FVC and FEV1 in the development cohort, as well as in the validation cohort. The predicted postoperative FEV1 (ppo%FEV1) calculated based on the regression equation was also correlated with the postoperative FEV1 value obtained by the conventional method (R=0.53), and the regression equation-based ppo%FEV1 was a significant predictor of postoperative cardiopulmonary complications (P=0.02). CONCLUSIONS: Whole lung CT can be used to assess the preoperative pulmonary function in patients undergoing lobectomy for cancer. This method may be helpful in preoperative risk assessment, particularly in patients who have difficulty in implementation of spirometry.
Authors: Daniel M Libby; James P Smith; Nasser K Altorki; Mark W Pasmantier; David Yankelevitz; Claudia I Henschke Journal: Chest Date: 2004-04 Impact factor: 9.410