Guo-Zhe Sun1, Hao-Yu Wang1, Ning Ye1, Ying-Xian Sun2. 1. Department of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China. 2. Department of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address: yxsun@cmu.edu.cn.
Abstract
BACKGROUND: Recently, the novel Peguero-Lo Presti electrocardiographic criteria to diagnose left ventricular hypertrophy (LVH) were developed from Caucasian American population with a relatively high sensitivity. However, further validation on a large Asian population has never been conducted. Thus, this study was to test and validate the overall performance of this index in a general population from China. METHODS: A total of 10,614 permanent residents ≥35 years of age were included in this study. All participants completed 12-lead electrocardiography and echocardiography at the same visit. A receiver-operating characteristic curve was used for comparing the performance of electrocardiographic indices in diagnosing echocardiographic LVH. RESULTS: The Peguero-Lo Presti criteria had higher sensitivity but lower specificity than Cornell and Sokolow-Lyon voltage according to the recommended criteria. The area under the curve of this novel Peguero-Lo Presti voltage was lower than that of Cornell for predicting LVH defined by both left ventricular mass/body surface area (0.665 vs 0.699 in males; 0.689 vs 0.721 in females) and left ventricular mass/height2.7 (0.623 vs 0.681 in males; 0.642 vs 0.709 in females) (all Ps < 0.05). By changing cutoff values, Cornell voltage outperformed Peguero-Lo Presti whether to achieve a relatively high sensitivity or specificity. CONCLUSIONS: The novel Peguero-Lo Presti voltage may not be a better screening tool for LVH in Asian population. In comparison with this new index, Cornell voltage could be a better screening test for LVH by changing its cutoff values to obtain maximum sensitivity.
BACKGROUND: Recently, the novel Peguero-Lo Presti electrocardiographic criteria to diagnose left ventricular hypertrophy (LVH) were developed from Caucasian American population with a relatively high sensitivity. However, further validation on a large Asian population has never been conducted. Thus, this study was to test and validate the overall performance of this index in a general population from China. METHODS: A total of 10,614 permanent residents ≥35 years of age were included in this study. All participants completed 12-lead electrocardiography and echocardiography at the same visit. A receiver-operating characteristic curve was used for comparing the performance of electrocardiographic indices in diagnosing echocardiographic LVH. RESULTS: The Peguero-Lo Presti criteria had higher sensitivity but lower specificity than Cornell and Sokolow-Lyon voltage according to the recommended criteria. The area under the curve of this novel Peguero-Lo Presti voltage was lower than that of Cornell for predicting LVH defined by both left ventricular mass/body surface area (0.665 vs 0.699 in males; 0.689 vs 0.721 in females) and left ventricular mass/height2.7 (0.623 vs 0.681 in males; 0.642 vs 0.709 in females) (all Ps < 0.05). By changing cutoff values, Cornell voltage outperformed Peguero-Lo Presti whether to achieve a relatively high sensitivity or specificity. CONCLUSIONS: The novel Peguero-Lo Presti voltage may not be a better screening tool for LVH in Asian population. In comparison with this new index, Cornell voltage could be a better screening test for LVH by changing its cutoff values to obtain maximum sensitivity.
Authors: Jean Jacques Noubiap; Thomas A Agbaedeng; Ulrich Flore Nyaga; Clovis Nkoke; Ahmadou M Jingi Journal: J Clin Hypertens (Greenwich) Date: 2020-07-01 Impact factor: 3.738
Authors: Caio de Assis Moura Tavares; Nelson Samesima; Ludhmila Abrahão Hajjar; Lucas C Godoy; Eduardo Messias Hirano Padrão; Felippe Lazar Neto; Mirella Facin; Wilson Jacob-Filho; Michael E Farkouh; Carlos Alberto Pastore Journal: Sci Rep Date: 2021-06-01 Impact factor: 4.379