Ioan Sporea1, Ruxandra Mare2, Raluca Lupusoru3, Alina Popescu4, Mirela Danila5, Felix Bende6, Roxana Sirli7. 1. Department of Gastroenterology and Hepatology, Victor Babes University of Medicine and Pharmacy Timişoara, Romania. isporea@umft.ro. 2. Department of Gastroenterology and Hepatology, Victor Babes University of Medicine and Pharmacy Timişoara, Romania. ruxi2323@yahoo.com. 3. Department of Gastroenterology and Hepatology, Victor Babes University of Medicine and Pharmacy Timişoara, Romania. raluca_lupusoru@yahoo.ro. 4. Department of Gastroenterology and Hepatology, Victor Babes University of Medicine and Pharmacy Timişoara, Romania. alinamircea.popescu@gmail.com. 5. Department of Gastroenterology and Hepatology, Victor Babes University of Medicine and Pharmacy Timişoara, Romania. mireladanila@gmail.com. 6. Department of Gastroenterology and Hepatology, Victor Babes University of Medicine and Pharmacy Timişoara, Romania. bendefelix@gmail.com. 7. Department of Gastroenterology and Hepatology, Victor Babes University of Medicine and Pharmacy Timişoara, Romania. roxanasirli@gmail.com.
Abstract
AIMS: Non-invasive methods to assess the severity of chronic liver diseases have become more and more popular. The aim of our study was to evaluate the correlation of four Shear Waves Elastographic methods in a cohort of patients with chronic liver diseases of mixed etiologies and to compare their performances for liver fibrosis evaluation. MATERIAL AND METHODS: A prospective study was conducted on 127 consecutive patients with chronic liver diseases of mixed etiologies. LS measurements were performed in all subjects, in one session, during the same day, by means of 4 elastographic methods: Transient Elastography (TE), Virtual Touch Quantification (VTQ), ElastPQ and 2D-SWE.SSI. The diagnosis accuracies of VTQ, ElastPQ, 2D-SWE.SSI were then compared using TE as reference method. RESULTS: Valid LS measurements by all four shear waves ultrasound elastographic methods were obtained in 116/127 subjects with VTQ, in 108/127 subjects with 2D-SWE.SSI, in 111/127 with TE and in 109/127 with ElastPQ, so the final analysis included 82/127 subjects (64.5%). A good and significant correlation was found between all 4 elastographic methods. The diagnostic accuracy of VTQ, 2D-SWE.SSI and ElastPQ for the diagnosis of significant and severe fibrosis (F2/F3), and liver cirrhosis were similar for all elastographic techniques: VTQ vs 2D-SWE.SSI vs ElastPQ: 84.1% vs 85.3% vs. 84% (p>0.05); 93.9% vs 94% vs 94% (p>0.05). CONCLUSION: considering TE as the reference method for liver fibrosis evaluation, VTQ, ElastPQ, and 2D-SWE.SSI obtained similar accuracies for diagnosing at least significant fibrosis (F≥2) and liver cirrhosis.
AIMS: Non-invasive methods to assess the severity of chronic liver diseases have become more and more popular. The aim of our study was to evaluate the correlation of four Shear Waves Elastographic methods in a cohort of patients with chronic liver diseases of mixed etiologies and to compare their performances for liver fibrosis evaluation. MATERIAL AND METHODS: A prospective study was conducted on 127 consecutive patients with chronic liver diseases of mixed etiologies. LS measurements were performed in all subjects, in one session, during the same day, by means of 4 elastographic methods: Transient Elastography (TE), Virtual Touch Quantification (VTQ), ElastPQ and 2D-SWE.SSI. The diagnosis accuracies of VTQ, ElastPQ, 2D-SWE.SSI were then compared using TE as reference method. RESULTS: Valid LS measurements by all four shear waves ultrasound elastographic methods were obtained in 116/127 subjects with VTQ, in 108/127 subjects with 2D-SWE.SSI, in 111/127 with TE and in 109/127 with ElastPQ, so the final analysis included 82/127 subjects (64.5%). A good and significant correlation was found between all 4 elastographic methods. The diagnostic accuracy of VTQ, 2D-SWE.SSI and ElastPQ for the diagnosis of significant and severe fibrosis (F2/F3), and liver cirrhosis were similar for all elastographic techniques: VTQ vs 2D-SWE.SSI vs ElastPQ: 84.1% vs 85.3% vs. 84% (p>0.05); 93.9% vs 94% vs 94% (p>0.05). CONCLUSION: considering TE as the reference method for liver fibrosis evaluation, VTQ, ElastPQ, and 2D-SWE.SSI obtained similar accuracies for diagnosing at least significant fibrosis (F≥2) and liver cirrhosis.
Authors: Dong Won Park; Yoon Jin Lee; Won Chang; Ji Hoon Park; Kyoung Ho Lee; Young Hoon Kim; Nam Kyu Kang; Jung Wha Chung; Hee Yoon Jang; Soomin Ahn; Haeryoung Kim; Sook-Hyang Jeong; Jin-Wook Kim; Eun Sun Jang Journal: PLoS One Date: 2019-03-11 Impact factor: 3.240