| Literature DB >> 30166436 |
Li Guo1,2,3, Thilo Winzer4, Xiaofei Yang1,5, Yi Li4, Zemin Ning6, Zhesi He4, Roxana Teodor4, Ying Lu7, Tim A Bowser8, Ian A Graham9, Kai Ye10,2,3,11.
Abstract
Morphinan-based painkillers are derived from opium poppy (Papaver somniferum L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. Synteny analysis suggests a whole-genome duplication at ~7.8 million years ago and ancient segmental or whole-genome duplication(s) that occurred before the Papaveraceae-Ranunculaceae divergence 110 million years ago. Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provide insight into how this cluster evolved. Paralog analysis identified P450 and oxidoreductase genes that combined to form the STORR gene fusion essential for morphinan biosynthesis in opium poppy. Thus, gene duplication, rearrangement, and fusion events have led to evolution of specialized metabolic products in opium poppy.Entities:
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Year: 2018 PMID： 30166436 DOI： 10.1126/science.aat4096
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728