Davis A Englund1, Lori Lyn Price2,3, Gregory J Grosicki1, Megumi Iwai4, Makoto Kashiwa4, Christine Liu1,5, Kieran F Reid1, Roger A Fielding1. 1. Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts. 2. Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts. 3. Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts. 4. Astellas Pharma, Tokyo, Japan. 5. Geriatrics Section, Department of Medicine, Boston Medical Center, Massachusetts.
Abstract
BACKGROUND: Progressive resistance training (PRT) is consistently shown to improve muscle strength in older adults. The efficacy of PRT to improve muscle fatigue in older adults with demonstrated mobility limitations remains unclear. METHODS: Mobility-limited (Short Physical Performance Battery [SPPB] ≤ 9) older adults (age 70-92 years) were recruited for this study and randomized to either PRT or home-based flexibility (FLEX) 3 d/wk for 12 weeks. Muscle fatigue and strength outcomes were assessed at baseline and 12 weeks. The primary outcome was torque capacity, a composite measure of strength and fatigue, defined as the sum of peak torques from an isokinetic fatigue test. RESULTS: Seventy participants were randomized (mean [SD] age 78.9 [5.4] years; 60% female; mean [SD] SPPB 7.5 [1.6]). At follow-up, the PRT group improved significantly in torque capacity, mean between-group difference (95% confidence interval) 466.19 (138.4, 793.97) Nm (p = .006), and maximal strength 127.3 (60.96, 193.61) Nm (p = .0003), when compared with FLEX group. Neither group demonstrated significant changes in muscle fatigue or torque variability. CONCLUSION: Twelve weeks of PRT improved torque capacity, as well as strength in mobility-limited older adults. These results demonstrate PRT improves multiple age-related muscular impairments.
BACKGROUND: Progressive resistance training (PRT) is consistently shown to improve muscle strength in older adults. The efficacy of PRT to improve muscle fatigue in older adults with demonstrated mobility limitations remains unclear. METHODS: Mobility-limited (Short Physical Performance Battery [SPPB] ≤ 9) older adults (age 70-92 years) were recruited for this study and randomized to either PRT or home-based flexibility (FLEX) 3 d/wk for 12 weeks. Muscle fatigue and strength outcomes were assessed at baseline and 12 weeks. The primary outcome was torque capacity, a composite measure of strength and fatigue, defined as the sum of peak torques from an isokinetic fatigue test. RESULTS: Seventy participants were randomized (mean [SD] age 78.9 [5.4] years; 60% female; mean [SD] SPPB 7.5 [1.6]). At follow-up, the PRT group improved significantly in torque capacity, mean between-group difference (95% confidence interval) 466.19 (138.4, 793.97) Nm (p = .006), and maximal strength 127.3 (60.96, 193.61) Nm (p = .0003), when compared with FLEX group. Neither group demonstrated significant changes in muscle fatigue or torque variability. CONCLUSION: Twelve weeks of PRT improved torque capacity, as well as strength in mobility-limited older adults. These results demonstrate PRT improves multiple age-related muscular impairments.
Authors: Dylan R Kirn; Kieran F Reid; Cynthia Hau; Edward M Phillips; Roger A Fielding Journal: J Gerontol A Biol Sci Med Sci Date: 2015-11-18 Impact factor: 6.053
Authors: Roger A Fielding; Nathan K LeBrasseur; Anthony Cuoco; Jonathan Bean; Kelly Mizer; Maria A Fiatarone Singh Journal: J Am Geriatr Soc Date: 2002-04 Impact factor: 5.562
Authors: Donato A Rivas; Sarah J Lessard; Nicholas P Rice; Michael S Lustgarten; Kawai So; Laurie J Goodyear; Laurence D Parnell; Roger A Fielding Journal: FASEB J Date: 2014-06-13 Impact factor: 5.191
Authors: Kieran F Reid; Damien M Callahan; Robert J Carabello; Edward M Phillips; Walter R Frontera; Roger A Fielding Journal: Aging Clin Exp Res Date: 2008-08 Impact factor: 3.636
Authors: Jane A Kent-Braun; Damien M Callahan; Jessica L Fay; Stephen A Foulis; John P Buonaccorsi Journal: Muscle Nerve Date: 2013-06-06 Impact factor: 3.217
Authors: Jean-Yves Reginster; Cyrus Cooper; René Rizzoli; John A Kanis; Geoff Appelboom; Ivan Bautmans; Heike A Bischoff-Ferrari; Maarten Boers; Maria Luisa Brandi; Olivier Bruyère; Antonio Cherubini; Bruno Flamion; Roger A Fielding; Andrea Ildiko Gasparik; Luc Van Loon; Eugene McCloskey; Bruce H Mitlak; Alberto Pilotto; Suzanne Reiter-Niesert; Yves Rolland; Yannis Tsouderos; Marjolein Visser; Alfonso J Cruz-Jentoft Journal: Aging Clin Exp Res Date: 2015-12-30 Impact factor: 3.636
Authors: J Max Michel; Kristy K Lievense; Sam C Norton; Juliana V Costa; Kathryn H Alphin; Lydia A Bailey; Gary D Miller Journal: Nutrients Date: 2022-06-30 Impact factor: 6.706
Authors: Janet Withall; Colin J Greaves; Janice L Thompson; Jolanthe L de Koning; Jessica C Bollen; Sarah J Moorlock; Kenneth R Fox; Max J Western; Tristan Snowsill; Antonieta Medina-Lara; Rosina Cross; Peter Ladlow; Gordon Taylor; Vasiliki Zisi; James Clynes; Selena Gray; Sandra Agyapong-Badu; Jack M Guralnik; W Jack Rejeski; Afroditi Stathi Journal: J Gerontol A Biol Sci Med Sci Date: 2020-11-13 Impact factor: 6.053