Åsa H Everhov1,2, Hamed Khalili2,3, Johan Askling2, Pär Myrelid4, Jonas F Ludvigsson5,6, Jonas Halfvarson7, Caroline Nordenvall8,9, Jonas Söderling2, Ola Olén1,2,10, Martin Neovius2. 1. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. 2. Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. 3. Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 4. Division of Surgery, Department of Clinical and Experimental Medicine, Faulty of Health Sciences, Linköping University and Department of Surgery, County Council of Östergötland Linköping, Sweden. 5. Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 6. Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden. 7. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. 8. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. 9. Center for Digestive Disease, Division of Coloproctology, Karolinska University Hospital, Stockholm, Sweden. 10. Department of Pediatric gastroenterology and Nutrition, Sachs' Children and Youth Hospital, Stockholm, Sweden.
Abstract
BACKGROUND AND AIMS: Crohn's disease may affect the ability to work and lead to permanent disability. We aimed to investigate work loss in prevalent patients. METHODS: We identified patients with Crohn's disease and general population comparators matched by sex, birth year, healthcare region and education. We assessed days of sick leave and disability pension retrieved from the Swedish Social Insurance Agency and estimated the absolute and relative risk of receiving disability pension [minimum 25% work impairment]. RESULTS: In 2014, the 20638 Crohn's disease patients [median age 44 years] had more than twice as many mean lost workdays [disability pension: 44; sick leave: 19] as the 102038 comparators [disability pension: 20; sick leave: 8], mean difference 35 days [95% confidence interval 33-37]. However, the majority had no lost workdays [68% of patients and 85% of comparators]. The proportion of patients receiving disability pension was 15% (6.5% in the comparators, risk ratio 2.34 [2.25-2.43]) and was higher in all subgroups, especially in female patients [28% vs 13% in the comparators], in those with ≤9 years of education [41% vs 23%] and in ages 60-64 years [46% vs 25%]. The relative risk of disability pension within the patient cohort [adjusted for age, sex, region and education] was higher in patients with complicated disease behaviour, extraintestinal manifestations, need of surgery or treatment with biologics. The differences between patients and comparators remained when comparing other calendar years [2006-2013]. CONCLUSION: Work loss was found in approximately one-third of patients. The mean number of lost workdays was twice as high as in the comparators.
BACKGROUND AND AIMS: Crohn's disease may affect the ability to work and lead to permanent disability. We aimed to investigate work loss in prevalent patients. METHODS: We identified patients with Crohn's disease and general population comparators matched by sex, birth year, healthcare region and education. We assessed days of sick leave and disability pension retrieved from the Swedish Social Insurance Agency and estimated the absolute and relative risk of receiving disability pension [minimum 25% work impairment]. RESULTS: In 2014, the 20638 Crohn's disease patients [median age 44 years] had more than twice as many mean lost workdays [disability pension: 44; sick leave: 19] as the 102038 comparators [disability pension: 20; sick leave: 8], mean difference 35 days [95% confidence interval 33-37]. However, the majority had no lost workdays [68% of patients and 85% of comparators]. The proportion of patients receiving disability pension was 15% (6.5% in the comparators, risk ratio 2.34 [2.25-2.43]) and was higher in all subgroups, especially in female patients [28% vs 13% in the comparators], in those with ≤9 years of education [41% vs 23%] and in ages 60-64 years [46% vs 25%]. The relative risk of disability pension within the patient cohort [adjusted for age, sex, region and education] was higher in patients with complicated disease behaviour, extraintestinal manifestations, need of surgery or treatment with biologics. The differences between patients and comparators remained when comparing other calendar years [2006-2013]. CONCLUSION: Work loss was found in approximately one-third of patients. The mean number of lost workdays was twice as high as in the comparators.
Authors: Adrian Salinas Fredricson; Carina Krüger Weiner; Johanna Adami; Annika Rosén; Bodil Lund; Britt Hedenberg-Magnusson; Lars Fredriksson; Pia Svedberg; Aron Naimi-Akbar Journal: BMC Public Health Date: 2022-05-09 Impact factor: 4.135
Authors: Hamed Khalili; Åsa H Everhov; Jonas Halfvarson; Jonas F Ludvigsson; Johan Askling; Pär Myrelid; Jonas Söderling; Ola Olen; Martin Neovius Journal: Aliment Pharmacol Ther Date: 2020-07-03 Impact factor: 9.524
Authors: Johan Lundberg; Thomas Cars; Sven-Åke Lööv; Jonas Söderling; Jari Tiihonen; Amy Leval; Anna Gannedahl; Carl Björkholm; Mikael Själin; Clara Hellner Journal: Acta Psychiatr Scand Date: 2022-03-02 Impact factor: 7.734
Authors: Petter Malmborg; Åsa H Everhov; Jonas Söderling; Jonas F Ludvigsson; Gustaf Bruze; Ola Olén Journal: Aliment Pharmacol Ther Date: 2022-08-02 Impact factor: 9.524
Authors: Åsa H Everhov; Michael C Sachs; Jonas F Ludvigsson; Hamed Khalili; Johan Askling; Martin Neovius; Pär Myrelid; Jonas Halfvarson; Caroline Nordenvall; Jonas Söderling; Ola Olén Journal: Clin Epidemiol Date: 2020-03-10 Impact factor: 4.790
Authors: Jonas F Ludvigsson; Ola Olén; Henrik Larsson; Jonas Halfvarson; Catarina Almqvist; Paul Lichtenstein; Agnieszka Butwicka Journal: J Crohns Colitis Date: 2021-11-08 Impact factor: 9.071
Authors: Åsa H Everhov; Gustaf Bruze; Jonas Söderling; Johan Askling; Jonas Halfvarson; Karin Westberg; Petter Malmborg; Caroline Nordenvall; Jonas F Ludvigsson; Ola Olén Journal: J Crohns Colitis Date: 2021-06-22 Impact factor: 9.071