Literature DB >> 3015658

What do GABA neurons really do? They make possible variability generation in relation to demand.

E Roberts.   

Abstract

It is proposed that GABA neurons play key roles in maintaining meaningful communications within and among neural units by making possible variability generation in relation to demand. Activities of GABAergic inhibitory projection neurons from command centers and local circuit GABAergic inhibitory interneurons allow adaptive nervous system function to take place in a manner characterized by freedom without license. Through their multiple activities and connections these neurons make possible smooth transitions between modes of nervous system function over a range of increasing demands (neural pressures), enabling organisms to explore full ranges of their options.

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Year:  1986        PMID: 3015658     DOI: 10.1016/0014-4886(86)90189-5

Source DB:  PubMed          Journal:  Exp Neurol        ISSN: 0014-4886            Impact factor:   5.330


  11 in total

Review 1.  Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships.

Authors:  Renê Oliveira Beleboni; Ruither Oliveira Gomes Carolino; Andrea Baldocchi Pizzo; Lissandra Castellan-Baldan; Joaquim Coutinho-Netto; Wagner Ferreira dos Santos; Norberto Cysne Coimbra
Journal:  Cell Mol Neurobiol       Date:  2004-12       Impact factor: 5.046

Review 2.  Inhibition in the nervous system: models of its roles in choice and context determination.

Authors:  D S Levine; S J Leven
Journal:  Neurochem Res       Date:  1991-03       Impact factor: 3.996

Review 3.  GABA as a Neurotransmitter in Gastropod Molluscs.

Authors:  Mark W Miller
Journal:  Biol Bull       Date:  2019-01-16       Impact factor: 1.818

Review 4.  Living systems are tonically inhibited, autonomous optimizers, and disinhibition coupled to variability generation is their major organizing principle: inhibitory command-control at levels of membrane, genome, metabolism, brain, and society.

Authors:  E Roberts
Journal:  Neurochem Res       Date:  1991-03       Impact factor: 3.996

5.  The effects of volatile anesthetics on the extracellular accumulation of [(3)H]GABA in rat brain cortical slices.

Authors:  Paulo H C Diniz; Cristina Guatimosim; Nancy S Binda; Flávia L P Costa; Marcus V Gomez; Renato S Gomez
Journal:  Cell Mol Neurobiol       Date:  2013-10-01       Impact factor: 5.046

Review 6.  The rhythmic GABAergic system.

Authors:  D P Cardinali; D A Golombek
Journal:  Neurochem Res       Date:  1998-05       Impact factor: 3.996

7.  Presynaptic effects of gamma-aminobutyric acid on norepinephrine release and uptake in rat pineal gland.

Authors:  R E Rosenstein; H E Chuluyan; D P Cardinali
Journal:  J Neural Transm Gen Sect       Date:  1990

Review 8.  GABA--the quintessential neurotransmitter: electroneutrality, fidelity, specificity, and a model for the ligand binding site of GABAA receptors.

Authors:  E Roberts; M A Sherman
Journal:  Neurochem Res       Date:  1993-04       Impact factor: 3.996

9.  Human breast cancer metastases to the brain display GABAergic properties in the neural niche.

Authors:  Josh Neman; John Termini; Sharon Wilczynski; Nagarajan Vaidehi; Cecilia Choy; Claudia M Kowolik; Hubert Li; Amanda C Hambrecht; Eugene Roberts; Rahul Jandial
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-06       Impact factor: 11.205

10.  GABA-immunoreactive neurons in the photosensory pineal organ of the rainbow trout: two distinct neuronal populations.

Authors:  P Ekström; T van Veen; A Bruun; B Ehinger
Journal:  Cell Tissue Res       Date:  1987-10       Impact factor: 5.249

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