Literature DB >> 3015365

Calcitonin gene-related peptide (CGRP) acts independently of calcitonin on cyclic AMP formation in clonal osteogenic sarcoma cells (UMR 106-01).

V P Michelangeli, D M Findlay, A Fletcher, T J Martin.   

Abstract

In several human cancer cell lines and in a subclone of rat osteogenic sarcoma cells (UMR 106-06) possessing calcitonin receptors and a calcitonin-responsive adenylate cyclase, calcitonin gene-related peptide (CGRP) behaved as a weak calcitonin agonist. In another subclone of the same osteogenic sarcoma (UMR 106-01) with no measurable calcitonin receptors or response, both rat and human CGRP were found to increase cyclic AMP formation in a dose-dependent manner. The data indicate that CGRP is capable of a weak calcitonin-like action in cells with calcitonin receptors, but also that in some cells CGRP activates adenylate cyclase itself, independently of calcitonin receptors.

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Year:  1986        PMID： 3015365     DOI： 10.1007/bf02555739

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  20 in total

1.  A highly sensitive adenylate cyclase assay.

Authors:  Y Salomon; C Londos; M Rodbell
Journal:  Anal Biochem       Date:  1974-04       Impact factor: 3.365

2.  Calcitonin receptors in a cloned human breast cancer cell line (MCF 7).

Authors:  T J Martin; D M Findlay; I MacIntyre; J A Eisman; V P Michelangeli; J M Moseley; N C Partridge
Journal:  Biochem Biophys Res Commun       Date:  1980-09-16       Impact factor: 3.575

3.  Receptors for 1,25(OH)2-vitamin D3 enriched in cloned osteoblast-like rat osteogenic sarcoma cells.

Authors:  N C Partridge; R J Frampton; J A Eisman; V P Michelangeli; E Elms; T R Bradley; T J Martin
Journal:  FEBS Lett       Date:  1980-06-16       Impact factor: 4.124

4.  Calcitonin and 1,25-dihydroxyvitamin D3 receptors in human breast cancer cell lines.

Authors:  D M Findlay; V P Michelangeli; J A Eisman; R J Frampton; J M Moseley; I MacIntyre; R Whitehead; T J Martin
Journal:  Cancer Res       Date:  1980-12       Impact factor: 12.701

5.  Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.

Authors:  S G Amara; V Jonas; M G Rosenfeld; E S Ong; R M Evans
Journal:  Nature       Date:  1982-07-15       Impact factor: 49.962

6.  Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells.

Authors:  V P Michelangeli; S A Livesey; T J Martin
Journal:  Biochem J       Date:  1984-12-01       Impact factor: 3.857

7.  Isolation and characterization of human calcitonin gene-related peptide.

Authors:  H R Morris; M Panico; T Etienne; J Tippins; S I Girgis; I MacIntyre
Journal:  Nature       Date:  1984 Apr 19-25       Impact factor: 49.962

8.  The myotropic and plasma-calcium modulating effects of calcitonin gene-related peptide (CGRP).

Authors:  J R Tippins; H R Morris; M Panico; T Etienne; P Bevis; S Girgis; I MacIntyre; M Azria; M Attinger
Journal:  Neuropeptides       Date:  1984-09       Impact factor: 3.286

9.  Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites.

Authors:  S G Amara; R M Evans; M G Rosenfeld
Journal:  Mol Cell Biol       Date:  1984-10       Impact factor: 4.272

10.  Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing.

Authors:  M G Rosenfeld; J J Mermod; S G Amara; L W Swanson; P E Sawchenko; J Rivier; W W Vale; R M Evans
Journal:  Nature       Date:  1983 Jul 14-20       Impact factor: 49.962
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  5 in total

1.  Neuroendocrine peptides in bone.

Authors:  A Bjurholm
Journal:  Int Orthop       Date:  1991       Impact factor: 3.075

2.  Structure-activity relationship of human calcitonin-gene-related peptide.

Authors:  M Zaidi; S D Brain; J R Tippins; V Di Marzo; B S Moonga; T J Chambers; H R Morris; I MacIntyre
Journal:  Biochem J       Date:  1990-08-01       Impact factor: 3.857

3.  Pasteurella multocida toxin is a mitogen for bone cells in primary culture.

Authors:  P B Mullan; A J Lax
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441

4.  Calcitonin gene-related peptide (CGRP) activates human neutrophils--inhibition by chemotactic peptide antagonist BOC-MLP.

Authors:  J Richter; R Andersson; L Edvinsson; U Gullberg
Journal:  Immunology       Date:  1992-11       Impact factor: 7.397

5.  Human placental calcitonin receptors.

Authors:  G C Nicholson; C S D'Santos; T Evans; J M Moseley; B E Kemp; V P Michelangeli; T J Martin
Journal:  Biochem J       Date:  1988-03-15       Impact factor: 3.857
  5 in total

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