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Literature DB >> 3015077

Patterns of polypeptide synthesis in human rotavirus infected cells.

T Sato, H Suzuki, S Kitaoka, T Konno, N Ishida.

Abstract

Polypeptide analysis of three strains of human rotavirus (KUN, Wa and MO) were conducted using a hypertonic culture which suppressed host protein synthesis and unmasked rotavirus specific protein synthesis. As a result, eleven human rotavirus specific polypeptides (Vp 1--Vp 11) were detected by pulselabeling infected cells with [14C]-leucine. Among the 11 polypeptides, three polypeptides (Vp 7, Vp 10 and Vp 11) underwent post-translational processing, and two (Vp 7 and Vp 10) were glycosylated. Six polypeptides (Vp 1, 2, 3, 4, 6 and 7) were identified as viral structural proteins. Comparisons of three strains of different serotypes revealed that their polypeptide profiles differed from each other in electrophoretic mobility; in particular, profiles of the glycosylated polypeptide, Vp 7, were distinct among the three strains.

Entities: Disease Species

Mesh：

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Year: 1986 PMID： 3015077 DOI： 10.1007/bf01314142

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

24 in total

1. Further biochemical characterization, including the detection of surface glycoproteins, of human, calf, and simian rotaviruses.

Authors: S M Rodger; R D Schnagl; I H Holmes
Journal: J Virol Date: 1977-10 Impact factor: 5.103

6. Rotavirus antagonizes cellular antiviral responses by inhibiting the nuclear accumulation of STAT1, STAT2, and NF-kappaB.

Authors: Gavan Holloway; Thanhmai T Truong; Barbara S Coulson
Journal: J Virol Date: 2009-02-25 Impact factor: 5.103

6 in total

Patterns of polypeptide synthesis in human rotavirus infected cells.

1. Further biochemical characterization, including the detection of surface glycoproteins, of human, calf, and simian rotaviruses.

2. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

3. Trypsin enhancement of rotavirus infectivity: mechanism of enhancement.

4. Structural polypeptides of simian rotavirus SA11 and the effect of trypsin.

5. Isolation of human rotavirus subgroups 1 and 2 in cell culture.

6. In vitro transcription and translation of simian rotavirus SA11 gene products.

7. A new staining technique for proteins in polyacrylamide gels using coomassie brilliant blue G250.

8. Biochemical and biophysical characteristics of diarrhea viruses of human and calf origin.

9. Different polypeptide composition of two human rotavirus types.

10. Astrovirus-associated epidemic gastroenteritis in Japan.

1. Biochemical characterization of the structural and nonstructural polypeptides of a porcine group C rotavirus.

Review 2. Rotavirus gene structure and function.

3. Effect of trypsin and chymotrypsin on polypeptides of human rotavirus KUN strain.

4. NS35 and not vp7 is the soluble rotavirus protein which binds to target cells.

5. Role of VP3 in human rotavirus internalization after target cell attachment via VP7.

6. Rotavirus antagonizes cellular antiviral responses by inhibiting the nuclear accumulation of STAT1, STAT2, and NF-kappaB.