Literature DB >> 30150463

Caspofungin Modulates Ryanodine Receptor-Mediated Calcium Release in Human Cardiac Myocytes.

Christian Koch1, Jennifer Jersch2, Emmanuel Schneck2, Fabian Edinger2, Hagen Maxeiner2, Florian Uhle3, Markus A Weigand3, Melanie Markmann2, Michael Sander2, Michael Henrich4.   

Abstract

Recent studies showed that critically ill patients might be at risk for hemodynamic impairment during caspofungin (CAS) therapy. The aim of our present study was to examine the mechanisms behind CAS-induced cardiac alterations. We revealed a dose-dependent increase in intracellular Ca2+ concentration ([Ca2+]i) after CAS treatment. Ca2+ ions were found to be released from intracellular caffeine-sensitive stores, most probably via the activation of ryanodine receptors.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  adverse drug reaction; antifungal agents; cardiac output; cardiac toxicity

Mesh：

Substances：

Year:  2018        PMID： 30150463      PMCID： PMC6201063          DOI： 10.1128/AAC.01114-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients.

Authors:  O A Cornely; M Bassetti; T Calandra; J Garbino; B J Kullberg; O Lortholary; W Meersseman; M Akova; M C Arendrup; S Arikan-Akdagli; J Bille; E Castagnola; M Cuenca-Estrella; J P Donnelly; A H Groll; R Herbrecht; W W Hope; H E Jensen; C Lass-Flörl; G Petrikkos; M D Richardson; E Roilides; P E Verweij; C Viscoli; A J Ullmann
Journal:  Clin Microbiol Infect       Date:  2012-12       Impact factor: 8.067

Review 2.  The heart in sepsis: from basic mechanisms to clinical management.

Authors:  Alain Rudiger; Mervyn Singer
Journal:  Curr Vasc Pharmacol       Date:  2013-03-01       Impact factor: 2.719

3.  Cardiac response to centrally administered echinocandin antifungals.

Authors:  Kayla R Stover; John D Cleary
Journal:  J Pharm Pharmacol       Date:  2015-06-09       Impact factor: 3.765

Review 4.  Impact of special patient populations on the pharmacokinetics of echinocandins.

Authors:  Eline W Muilwijk; Vincent J C Lempers; David M Burger; Adilia Warris; Peter Pickkers; Rob E Aarnoutse; Roger J M Brüggemann
Journal:  Expert Rev Anti Infect Ther       Date:  2015-05-06       Impact factor: 5.091

5.  Ca(2+) homeostasis in sealed t-tubules of mouse ventricular myocytes.

Authors:  I Moench; A N Lopatin
Journal:  J Mol Cell Cardiol       Date:  2014-04-28       Impact factor: 5.000

6.  Cardiac effects of echinocandins after central venous administration in adult rats.

Authors:  Christian Koch; Florian Uhle; Matthias Wolff; Christoph Arens; Astrid Schulte; Ling Li; Bernd Niemann; Michael Henrich; Susanne Rohrbach; Markus A Weigand; Christoph Lichtenstern
Journal:  Antimicrob Agents Chemother       Date:  2014-12-29       Impact factor: 5.191

7.  Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor.

Authors:  Huihui Kong; Peter P Jones; Andrea Koop; Lin Zhang; Henry J Duff; S R Wayne Chen
Journal:  Biochem J       Date:  2008-09-15       Impact factor: 3.857

Review 8.  Antifungal-Associated Drug-Induced Cardiac Disease.

Authors:  John D Cleary; Kayla R Stover
Journal:  Clin Infect Dis       Date:  2015-12-01       Impact factor: 9.079

9.  Cardiac Effects of Echinocandins in Endotoxemic Rats.

Authors:  Christian Koch; Matthias Wolff; Michael Henrich; Markus A Weigand; Christoph Lichtenstern; Florian Uhle
Journal:  Antimicrob Agents Chemother       Date:  2015-10-26       Impact factor: 5.191

10.  Effects of echinocandin preparations on adult rat ventricular cardiomyocytes. Preliminary results of an in vitro study.

Authors:  C Arens; F Uhle; M Wolff; R Röhrig; C Koch; A Schulte; S Weiterer; M Henrich; M A Weigand; K-D Schlüter; C Lichtenstern
Journal:  Anaesthesist       Date:  2014-02-07       Impact factor: 1.041
View more
  3 in total

1.  Hemodynamic changes in surgical intensive care unit patients undergoing echinocandin treatment.

Authors:  Christian Koch; Emmanuel Schneck; Christoph Arens; Melanie Markmann; Michael Sander; Michael Henrich; Markus A Weigand; Christoph Lichtenstern
Journal:  Int J Clin Pharm       Date:  2019-11-21

2.  Caspofungin-Induced Cardiotoxicity in Patients Treating for Candidemia.

Authors:  Roya Sattarzadeh Badkoubeh; Mostafa Farajpour; Mohammadreza Salehi; Alborz Sherafati; Zahra Zamani; Omid Rezahosseini; Pejman Mansouri; Akram Sardari
Journal:  Toxics       Date:  2022-08-31

3.  Caspofungin induces the release of Ca2+ ions from internal stores by activating ryanodine receptor-dependent pathways in human tracheal epithelial cells.

Authors:  Sabrina Müller; Christian Koch; Sebastian Weiterer; Markus A Weigand; Michael Sander; Michael Henrich
Journal:  Sci Rep       Date:  2020-07-16       Impact factor: 4.379
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.