BACKGROUND/AIM: Etiopathogenesis of autism spectrum disorders (ASD) remains to be elucidated. Congenital infections, particularly viral infections, have repeatedly been associated with the onset of such disorders. Our study aimed at assessing the prevalence of herpes simplex type 1 and 2 (HSV1/2) congenital infections in patients with ASD. MATERIALS AND METHODS: In our case-control study, a total of 38 children with ASD were compared to 44 age- and sex-matched controls regarding the presence of HSV1/2 infection though viral DNA polymerase chain reaction performed on dried blood spots collected at birth. RESULTS: No HSV congenital infection was detected in either group. CONCLUSION: Our negative finding is in agreement with other studies that failed to demonstrate a definitive role of HSV on the onset of ASD. Further investigation of congenital HSV prevalence in larger and more powerful studies is needed to undeniably discard a role of such virus in the etiopathogenesis of ASD. Copyright
BACKGROUND/AIM: Etiopathogenesis of autism spectrum disorders (ASD) remains to be elucidated. Congenital infections, particularly viral infections, have repeatedly been associated with the onset of such disorders. Our study aimed at assessing the prevalence of herpes simplex type 1 and 2 (HSV1/2) congenital infections in patients with ASD. MATERIALS AND METHODS: In our case-control study, a total of 38 children with ASD were compared to 44 age- and sex-matched controls regarding the presence of HSV1/2 infection though viral DNA polymerase chain reaction performed on dried blood spots collected at birth. RESULTS: No HSV congenital infection was detected in either group. CONCLUSION: Our negative finding is in agreement with other studies that failed to demonstrate a definitive role of HSV on the onset of ASD. Further investigation of congenital HSV prevalence in larger and more powerful studies is needed to undeniably discard a role of such virus in the etiopathogenesis of ASD. Copyright
Authors: Giordano D'Urso; Bernardo Dell'Osso; Rodolfo Rossi; Andre Russowsky Brunoni; Marco Bortolomasi; Roberta Ferrucci; Alberto Priori; Andrea de Bartolomeis; Alfredo Carlo Altamura Journal: J Affect Disord Date: 2017-05-08 Impact factor: 4.839
Authors: P Sundström; P Juto; G Wadell; G Hallmans; A Svenningsson; L Nyström; J Dillner; L Forsgren Journal: Neurology Date: 2004-06-22 Impact factor: 9.910