OBJECTIVE: To investigate the association between human herpesviruses and multiple sclerosis (MS), as well as between measles virus and MS. METHODS: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. RESULTS: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly (borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles. CONCLUSION: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset.
OBJECTIVE: To investigate the association between human herpesviruses and multiple sclerosis (MS), as well as between measles virus and MS. METHODS: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. RESULTS: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly (borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles. CONCLUSION: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset.
Authors: Gloudina M Hon; Mogamat S Hassan; Susan J van Rensburg; Rajiv T Erasmus; Tandi E Matsha Journal: Metab Brain Dis Date: 2012-03-10 Impact factor: 3.584
Authors: Kassandra L Munger; Kira Hongell; Marianna Cortese; Julia Åivo; Merja Soilu-Hänninen; Heljä-Marja Surcel; Alberto Ascherio Journal: Ann Neurol Date: 2019-07-03 Impact factor: 10.422
Authors: Eric J Kildebeck; Ram Narayan; Avindra Nath; Howard Weiner; Shin Beh; Peter A Calabresi; Lawrence Steinman; Eugene O Major; Teresa C Frohman; Elliot M Frohman Journal: J Neurol Date: 2016-10-12 Impact factor: 4.849
Authors: M P Pender; P A Csurhes; A Lenarczyk; C M M Pfluger; S R Burrows Journal: J Neurol Neurosurg Psychiatry Date: 2008-11-17 Impact factor: 10.154