Joong-Min Kim1,2, Joong-Hyun Kim3,4, Byeong-Han Lee3, Seok Hwa Choi5. 1. e-Well Dental Hospital, Seoul, Republic of Korea. 2. Department of Dentistry, Graduate School of Medicine, Korea University, Seoul, Republic of Korea. 3. Laboratory Animal Center, Osong Medical Innovation Foundation, Cheongju, Republic of Korea. 4. Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea. 5. Department of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea shchoi@cbu.ac.kr.
Abstract
BACKGROUND/AIM: Lost alveolar bone is commonly restored by distraction osteogenesis or bone blocks for substantial vertical bone augmentation (VBA), that is applied in conjunction with a barrier system. This study was performed to determine whether volume control of a three-dimensional (3D) printed nylon cap in the rat calvarial partial thickness bone defect would induce qualitative and quantitative differences in vertical bone regeneration. MATERIALS AND METHODS: A rat calvarial partial thickness bone defect was prepared and the 3D cap covered the defect to induce VBA, while the control group was left without cap placement. After six weeks the animals were sacrificed, and the calvaria were prepared for micro-CT (μCT) and histology. RESULTS: Quantitative μCT results showed that our cap system has significant osteoconductive properties, and the histology slide revealed new bone filled inside the cap. CONCLUSION: The results clearly showed that this system was successful for VBA in a research animal model. Copyright
BACKGROUND/AIM: Lost alveolar bone is commonly restored by distraction osteogenesis or bone blocks for substantial vertical bone augmentation (VBA), that is applied in conjunction with a barrier system. This study was performed to determine whether volume control of a three-dimensional (3D) printed nylon cap in the rat calvarial partial thickness bone defect would induce qualitative and quantitative differences in vertical bone regeneration. MATERIALS AND METHODS: A rat calvarial partial thickness bone defect was prepared and the 3D cap covered the defect to induce VBA, while the control group was left without cap placement. After six weeks the animals were sacrificed, and the calvaria were prepared for micro-CT (μCT) and histology. RESULTS: Quantitative μCT results showed that our cap system has significant osteoconductive properties, and the histology slide revealed new bone filled inside the cap. CONCLUSION: The results clearly showed that this system was successful for VBA in a research animal model. Copyright
Authors: Roberta Fraioli; Khandmaa Dashnyam; Joong-Hyun Kim; Roman A Perez; Hae-Won Kim; Javier Gil; Maria-Pau Ginebra; José María Manero; Carlos Mas-Moruno Journal: Acta Biomater Date: 2016-07-29 Impact factor: 8.947
Authors: Jonas Anderud; Ryo Jimbo; Peter Abrahamsson; Sten G Isaksson; Erik Adolfsson; Johan Malmström; Yusuke Kozai; Fredrik Hallmer; Ann Wennerberg Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Date: 2014-07-03