Jonas Anderud1, Ryo Jimbo2, Peter Abrahamsson3, Sten G Isaksson3, Erik Adolfsson4, Johan Malmström3, Yusuke Kozai5, Fredrik Hallmer2, Ann Wennerberg2. 1. Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden; Maxillofacial Unit Halmstad, Region Halland, Halmstad, Sweden. Electronic address: jonas.anderud@regionhalland.se. 2. Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden. 3. Maxillofacial Unit Halmstad, Region Halland, Halmstad, Sweden. 4. Swedish Ceramic Institute, IVF, Mölndal, Sweden. 5. Department of Oral and Maxillofacial Radiology, Kanagawa Dental College, Yokosuka, Japan.
Abstract
OBJECTIVE: The purpose of this study was to evaluate 3-dimensionally whether vertical bone augmentation can be achieved using a hollow hydroxyapatite space-maintaining device in a rabbit calvarial model. Furthermore, different inner surface topographies, different permeabilities, and different porosities of the ceramic were tested to determine the optimal conditions for bone regeneration. STUDY DESIGN: A total of 48 hollow domes made of hydroxyapatite in 4 different designs were placed subperiosteally on rabbit skull bone. The rabbits were humanely killed after 12 weeks, and the results were analyzed 3-dimensionally using micro-computed tomography. RESULTS: The results suggest a larger production of bone volume when using an occlusive, dense hydroxyapatite space-maintaining device with a rough inner surface. CONCLUSIONS: Hydroxyapatite space-maintaining devices permit new bone formation and osteoconduction within the dome.
OBJECTIVE: The purpose of this study was to evaluate 3-dimensionally whether vertical bone augmentation can be achieved using a hollow hydroxyapatite space-maintaining device in a rabbit calvarial model. Furthermore, different inner surface topographies, different permeabilities, and different porosities of the ceramic were tested to determine the optimal conditions for bone regeneration. STUDY DESIGN: A total of 48 hollow domes made of hydroxyapatite in 4 different designs were placed subperiosteally on rabbit skull bone. The rabbits were humanely killed after 12 weeks, and the results were analyzed 3-dimensionally using micro-computed tomography. RESULTS: The results suggest a larger production of bone volume when using an occlusive, dense hydroxyapatite space-maintaining device with a rough inner surface. CONCLUSIONS:Hydroxyapatite space-maintaining devices permit new bone formation and osteoconduction within the dome.