Sarah A Orban1, Tanya A Karamchandani2,3, Leanne Tamm1,4, Craig A Sidol5, James Peugh1,4, Tanya E Froehlich1,4, William B Brinkman1,4, Nicole Estell1, Akemi E Mii1, Jeffery N Epstein1,4. 1. Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Center for ADHD, Cincinnati, Ohio. 2. Department of Rehabilitation Psychology/Neuropsychology, TIRR Memorial Hermann Rehabilitation Network, Houston, Texas. 3. Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Baylor University, Houston, Texas. 4. College of Medicine, University of Cincinnati, Cincinnati, Ohio. 5. Department of Psychology, University of Cincinnati, Cincinnati, Ohio.
Abstract
Objective: We aimed to (1) examine differences in observed visual attention and motor activity, as well as comprehension of a science video between children with and without attention-deficit/hyperactivity disorder (ADHD) and (2) explore if psychostimulant medication improves ADHD behaviors and comprehension of a science video in children with ADHD. Method: Children aged 7-11 with (n = 91) and without (n = 45) ADHD watched ascience video and then completed a comprehension test. Then, children with ADHD began a 4-week within-subject, randomized, double-blind crossover trial of methylphenidate (MPH). At post-testing, children were randomized to receive placebo or their optimal dosage, watched another science film, and completed a comprehension test. Results:Children with ADHD exhibited higher rates of motor activity during, and worse comprehension of material discussed within, the science video. Mediation models revealed that increased motor activity suppressed between-group differences in comprehension. MPH improved comprehension and visual attention, but not motor activity during the science video. Conclusion:Children with ADHD may benefit from MPH to improve comprehension of and sustained attention during audiovisually presented learning material.
RCT Entities:
Objective: We aimed to (1) examine differences in observed visual attention and motor activity, as well as comprehension of a science video between children with and without attention-deficit/hyperactivity disorder (ADHD) and (2) explore if psychostimulant medication improves ADHD behaviors and comprehension of a science video in children with ADHD. Method: Children aged 7-11 with (n = 91) and without (n = 45) ADHD watched a science video and then completed a comprehension test. Then, children with ADHD began a 4-week within-subject, randomized, double-blind crossover trial of methylphenidate (MPH). At post-testing, children were randomized to receive placebo or their optimal dosage, watched another science film, and completed a comprehension test. Results:Children with ADHD exhibited higher rates of motor activity during, and worse comprehension of material discussed within, the science video. Mediation models revealed that increased motor activity suppressed between-group differences in comprehension. MPH improved comprehension and visual attention, but not motor activity during the science video. Conclusion:Children with ADHD may benefit from MPH to improve comprehension of and sustained attention during audiovisually presented learning material.
Entities:
Keywords:
ADHD; listening comprehension; methylphenidate; motor activity; visual attention
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