Application of drug delivery systems for the controlled delivery of growth factors to treat nervous system injury.

Nervous system injury represent the most common injury and was unique clinical challenge. Using of growth factors (GFs) for the treatment of nervous system injury showed effectiveness in halting its process. However, simple application of GFs could not achieve high efficacy because of its rapid diffusion into body fluids and lost from the lesion site. The drug delivery systems (DDSs) construction used to deliver GFs were investigated so that they could surmount its rapid diffusion and retain at the injury site. This study summarizes commonly used DDSs for sustained release of GFs that provide neuroprotection or restoration effects for nervous system injury.