Dong-Wook Lee1, Min-Seok Kim1, Youn-Hee Lim2, Nami Lee3, Yun-Chul Hong4. 1. Department of Preventive Medicine, College of Medicine, Seoul National University, 103 Daehangno, Jongno-gu, Seoul 110-799, Republic of Korea. 2. Environmental Health Centre, College of Medicine, Seoul National University, Seoul, Republic of Korea; Institute of Environmental Medicine, Medical Research Centre, Seoul National University, Seoul, Republic of Korea. 3. Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea. 4. Department of Preventive Medicine, College of Medicine, Seoul National University, 103 Daehangno, Jongno-gu, Seoul 110-799, Republic of Korea; Environmental Health Centre, College of Medicine, Seoul National University, Seoul, Republic of Korea; Institute of Environmental Medicine, Medical Research Centre, Seoul National University, Seoul, Republic of Korea. Electronic address: ychong1@snu.ac.kr.
Abstract
BACKGROUND: Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional). METHODS: We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis. RESULTS: We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood. CONCLUSIONS: To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health hazard of DEHP, the most commonly used phthalate, to promote healthier neurodevelopment in children.
BACKGROUND:Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional). METHODS: We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis. RESULTS: We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood. CONCLUSIONS: To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health hazard of DEHP, the most commonly used phthalate, to promote healthier neurodevelopment in children.
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