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Literature DB >> 30145108

Metabolic Stress, Autophagy, and Cardiovascular Aging: from Pathophysiology to Therapeutics.

Jun Ren¹, James R Sowers², Yingmei Zhang³.

Abstract

Recent advances in health care have improved the management of cardiometabolic disorders, and prolonged lifespan. However, the ever-rising prevalence of metabolic stress related to obesity (insulin resistance, diabetes, hypertension, and dyslipidemia) has greatly challenged geriatric care. The ubiquitin-proteasome system and autophagy-lysosomal pathways represent two major, yet distinct cellular machineries, for degradation and removal of damaged or long-lived proteins and organelles; the function of which declines with aging. To seek new strategies for cardiovascular aging under various metabolic diseases, it is imperative to understand the precise role for metabolic stress and protein quality control, in particular autophagy, in premature cardiovascular aging. Targeting metabolic stress and autophagy may offer exciting new avenues for the management of cardiovascular aging.

Entities: Chemical Disease Gene Species

Keywords: autophagy; cardiovascular aging; metabolic stress; obesity

Mesh：

Year: 2018 PMID： 30145108 PMCID： PMC6151141 DOI： 10.1016/j.tem.2018.08.001

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

113 in total

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Journal: Circulation Date: 2018-03-27 Impact factor: 29.690

Review 7. The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target.

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8. Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation.

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Journal: Aging Cell Date: 2017-07-05 Impact factor: 9.304

9. Foxo3a-dependent Bim transcription protects mice from a high fat diet via inhibition of activation of the NLRP3 inflammasome by facilitating autophagy flux in Kupffer cells.

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10. Diabetes and Aging: Unique Considerations and Goals of Care.

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31 in total

Review 1. As time flies by: Investigating cardiac aging in the short-lived Drosophila model.

Authors: Anna C Blice-Baum; Maria Clara Guida; Paul S Hartley; Peter D Adams; Rolf Bodmer; Anthony Cammarato
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2018-11-27 Impact factor: 5.187

2. Retinal Nerve Fiber Layer Thickness Decrease in Obesity as a Marker of Neurodegeneration.

Authors: Rita Laiginhas; Marta Guimarães; Pedro Cardoso; Hugo Santos-Sousa; John Preto; Mário Nora; João Chibante; Fernando Falcão-Reis; Manuel Falcão
Journal: Obes Surg Date: 2019-07 Impact factor: 4.129

Review 3. Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next?

Authors: Moein Ala; Mahan Ala
Journal: ACS Pharmacol Transl Sci Date: 2021-11-01

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6. HTR2A promotes the development of cardiac hypertrophy by activating PI3K-PDK1-AKT-mTOR signaling.

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Journal: Cell Stress Chaperones Date: 2020-06-09 Impact factor: 3.667

Review 7. Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics.

Authors: Amir Ajoolabady; Shuyi Wang; Guido Kroemer; Josef M Penninger; Vladimir N Uversky; Domenico Pratico; Nils Henninger; Russel J Reiter; Askiel Bruno; Kaumudi Joshipura; Hamid Aslkhodapasandhokmabad; Daniel J Klionsky; Jun Ren
Journal: Pharmacol Ther Date: 2021-04-03 Impact factor: 13.400