Literature DB >> 33752254

Targeting autophagy in neurodegenerative diseases: From molecular mechanisms to clinical therapeutics.

Amir Ajoolabady1,2, Hamid Aslkhodapasandhokmabad3, Nils Henninger4,5, Laurie J Demillard6, Masoud Nikanfar1, Alireza Nourazarian1,2, Jun Ren6,7,8.   

Abstract

Many neurodegenerative diseases are associated with pathological aggregation of proteins in neurons. Autophagy is a natural self-cannibalization process that can act as a powerful mechanism to remove aged and damaged organelles as well as protein aggregates. It has been shown that promoting autophagy can attenuate or delay neurodegeneration by removing protein aggregates. In this paper, we will review the role of autophagy in Alzheimer's disease (AD), Parkinson's Disease (PD), and Huntington's Disease (HD) and discuss opportunities and challenges of targeting autophagy as a potential therapeutic avenue for treatment of these common neurodegenerative diseases.
© 2021 John Wiley & Sons Australia, Ltd.

Entities:  

Keywords:  Alzheimer's disease; Huntington's disease; Parkinson's disease; autophagy; neurodegenerative disease

Mesh：

Year:  2021        PMID： 33752254      PMCID： PMC8204470          DOI： 10.1111/1440-1681.13500

Source DB:  PubMed          Journal:  Clin Exp Pharmacol Physiol        ISSN： 0305-1870            Impact factor:   2.963


  114 in total

Review 1.  Canonical and non-canonical autophagy: variations on a common theme of self-eating?

Authors:  Patrice Codogno; Maryam Mehrpour; Tassula Proikas-Cezanne
Journal:  Nat Rev Mol Cell Biol       Date:  2011-12-14       Impact factor: 94.444

2.  Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study.

Authors:  W T Longstreth; T A Manolio; A Arnold; G L Burke; N Bryan; C A Jungreis; P L Enright; D O'Leary; L Fried
Journal:  Stroke       Date:  1996-08       Impact factor: 7.914

3.  Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy.

Authors:  Yinan Hua; Yingmei Zhang; Asli F Ceylan-Isik; Loren E Wold; Jennifer M Nunn; Jun Ren
Journal:  Basic Res Cardiol       Date:  2011-09-09       Impact factor: 17.165

4.  Early alterations of autophagy in Huntington disease-like mice.

Authors:  Mary Y Heng; Peter J Detloff; Henry L Paulson; Roger L Albin
Journal:  Autophagy       Date:  2010-11-16       Impact factor: 16.016

Review 5.  Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association.

Authors:  Philip B Gorelick; Angelo Scuteri; Sandra E Black; Charles Decarli; Steven M Greenberg; Costantino Iadecola; Lenore J Launer; Stephane Laurent; Oscar L Lopez; David Nyenhuis; Ronald C Petersen; Julie A Schneider; Christophe Tzourio; Donna K Arnett; David A Bennett; Helena C Chui; Randall T Higashida; Ruth Lindquist; Peter M Nilsson; Gustavo C Roman; Frank W Sellke; Sudha Seshadri
Journal:  Stroke       Date:  2011-07-21       Impact factor: 7.914

6.  Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.

Authors:  Patricia Spilman; Natalia Podlutskaya; Matthew J Hart; Jayanta Debnath; Olivia Gorostiza; Dale Bredesen; Arlan Richardson; Randy Strong; Veronica Galvan
Journal:  PLoS One       Date:  2010-04-01       Impact factor: 3.240

7.  Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

Authors:  Sovan Sarkar; Janet E Davies; Zebo Huang; Alan Tunnacliffe; David C Rubinsztein
Journal:  J Biol Chem       Date:  2006-12-20       Impact factor: 5.157

8.  Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease.

Authors:  Yuncheng Wu; Xinqun Li; Julie Xiaohong Zhu; Wenjie Xie; Weidong Le; Zhen Fan; Joseph Jankovic; Tianhong Pan
Journal:  Neurosignals       Date:  2011-07-22

9.  Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease.

Authors:  Manish Sharma; Sumitha Rajendrarao; Neelam Shahani; Uri Nimrod Ramírez-Jarquín; Srinivasa Subramaniam
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-24       Impact factor: 11.205

10.  Accumulation of amyloid-like Aβ1-42 in AEL (autophagy-endosomal-lysosomal) vesicles: potential implications for plaque biogenesis.

Authors:  Daijun Ling; Martha Magallanes; Paul M Salvaterra
Journal:  ASN Neuro       Date:  2014-03-12       Impact factor: 4.146
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  6 in total

Review 1.  ER stress in obesity pathogenesis and management.

Authors:  Amir Ajoolabady; Simin Liu; Daniel J Klionsky; Gregory Y H Lip; Jaakko Tuomilehto; Sina Kavalakatt; David M Pereira; Afshin Samali; Jun Ren
Journal:  Trends Pharmacol Sci       Date:  2021-12-08       Impact factor: 14.819

2.  Discovery of Molecular Networks of Neuroprotection Conferred by Brahmi Extract in Aβ42-Induced Toxicity Model of Drosophila melanogaster Using a Quantitative Proteomic Approach.

Authors:  Sayali Chandrashekhar Deolankar; Mohd Altaf Najar; Poornima Ramesh; Anagha Kanichery; Avinash K Kudva; Shamprasad Varija Raghu; T S Keshava Prasad
Journal:  Mol Neurobiol       Date:  2022-10-20       Impact factor: 5.682

Review 3.  Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics.

Authors:  Amir Ajoolabady; Shuyi Wang; Guido Kroemer; Josef M Penninger; Vladimir N Uversky; Domenico Pratico; Nils Henninger; Russel J Reiter; Askiel Bruno; Kaumudi Joshipura; Hamid Aslkhodapasandhokmabad; Daniel J Klionsky; Jun Ren
Journal:  Pharmacol Ther       Date:  2021-04-03       Impact factor: 13.400

Review 4.  Nutraceutical and Dietary Strategies for Up-Regulating Macroautophagy.

Authors:  Mark F McCarty
Journal:  Int J Mol Sci       Date:  2022-02-12       Impact factor: 5.923

Review 5.  ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments.

Authors:  Amir Ajoolabady; Dan Lindholm; Jun Ren; Domenico Pratico
Journal:  Cell Death Dis       Date:  2022-08-15       Impact factor: 9.685

Review 6.  Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age.

Authors:  Ashley Payne; Samuel Nahashon; Equar Taka; Getinet M Adinew; Karam F A Soliman
Journal:  Biomolecules       Date:  2022-02-25
  6 in total

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