Fei Wang1, Qing-E Zhang2, Ling Zhang7, Chee H Ng3, Gabor S Ungvari4, Zhen Yuan5, June Zhang6, Ling Zhang7, Yu-Tao Xiang8. 1. Guangdong Mental Health Center, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangdong Province, China. 2. The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. 3. Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia. 4. University of Notre Dame Australia & Graylands Hospital, Perth, Australia; Division of Psychiatry, University of Western Australia Medical School, Perth, Australia. 5. Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China. 6. School of Nursing, Sun Yat-sen University, Guangzhou, China. 7. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China. 8. Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China. Electronic address: xyutly@gmail.com.
Abstract
BACKGROUND: The prevalence of major depressive disorder (MDD) in Chinese older adults in epidemiological surveys have been inconsistent. We thus conducted a systematic review and meta-analysis of the pooled prevalence of MDD in older adults in China. METHODS: Two investigators independently conducted a systematic literature search in English (PubMed, EMBASE, PsycINFO and Cochrane Library) and Chinese (CNKI, Sinomed and Wan Fang) databases. Studies reporting the prevalence of MDD in older adults in China using diagnostic instruments were identified and analyzed using the Comprehensive Meta-Analysis program. RESULTS: A total of 28 studies with 76,432 subjects were included. The mean age ranged from 62.1 to 74.1 years. The point prevalence of MDD in older adults was 2.7% (95% CI: 2.1%-3.4%), 12-month prevalence was 2.3% (95% CI: 0.6%-8.5%), and lifetime prevalence was 2.8% (95% CI: 1.8%-4.4%). Subgroup analyses revealed significant differences in the prevalence of MDD across regions. CONCLUSION: The prevalence of MDD in older adults varied across different regions in China. Further epidemiological studies and service planning should take into account such differences.
BACKGROUND: The prevalence of major depressive disorder (MDD) in Chinese older adults in epidemiological surveys have been inconsistent. We thus conducted a systematic review and meta-analysis of the pooled prevalence of MDD in older adults in China. METHODS: Two investigators independently conducted a systematic literature search in English (PubMed, EMBASE, PsycINFO and Cochrane Library) and Chinese (CNKI, Sinomed and Wan Fang) databases. Studies reporting the prevalence of MDD in older adults in China using diagnostic instruments were identified and analyzed using the Comprehensive Meta-Analysis program. RESULTS: A total of 28 studies with 76,432 subjects were included. The mean age ranged from 62.1 to 74.1 years. The point prevalence of MDD in older adults was 2.7% (95% CI: 2.1%-3.4%), 12-month prevalence was 2.3% (95% CI: 0.6%-8.5%), and lifetime prevalence was 2.8% (95% CI: 1.8%-4.4%). Subgroup analyses revealed significant differences in the prevalence of MDD across regions. CONCLUSION: The prevalence of MDD in older adults varied across different regions in China. Further epidemiological studies and service planning should take into account such differences.
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