Purpose: Human brown adipose tissue (BAT) has gained considerable attention as a potential therapeutic target for obesity and type 2 diabetes; however, whether physical activity (PA) might be an efficient stimulus to activate and recruit BAT remains to be ascertained. We aimed to examine whether objectively measured PA levels were associated with BAT volume and activity in young sedentary adults. We additionally examined the association of PA levels with the skeletal muscles activity. Methods: A total of 130 young healthy and sedentary adults (67% women; age, 21.9 ± 2.1 years old; body mass index, 25 ± 4.8 kg/m2) participated in this cross-sectional study. PA was objectively measured with a wrist-worn accelerometer for 7 consecutive days. Age-specific cut points were applied to classify wrist accelerations into sedentary time and different PA intensities (i.e., light, moderate, vigorous, moderate-vigorous). The participants underwent 2 hours of a personalized cold exposure to determine the cold-induced BAT volume and activity and the skeletal muscles activity by means of an 18F-fluorodeoxyglucose positron emission tomography combined with a CT scan. Results: Objectively measured PA intensity levels were neither associated with BAT volume and activity nor with the skeletal muscles activity (all P > 0.05). The results remained after adjusting for sex, waking time, and environmental temperature. Conclusions: Although PA plays an important role in the prevention of obesity and related comorbidities, it seems that other physiological mechanisms rather than brown adipocyte activation or recruitment might moderate its beneficial metabolic effects in young sedentary adults.
Purpose: Human brown adipose tissue (BAT) has gained considerable attention as a potential therapeutic target for obesity and type 2 diabetes; however, whether physical activity (PA) might be an efficient stimulus to activate and recruit BAT remains to be ascertained. We aimed to examine whether objectively measured PA levels were associated with BAT volume and activity in young sedentary adults. We additionally examined the association of PA levels with the skeletal muscles activity. Methods: A total of 130 young healthy and sedentary adults (67% women; age, 21.9 ± 2.1 years old; body mass index, 25 ± 4.8 kg/m2) participated in this cross-sectional study. PA was objectively measured with a wrist-worn accelerometer for 7 consecutive days. Age-specific cut points were applied to classify wrist accelerations into sedentary time and different PA intensities (i.e., light, moderate, vigorous, moderate-vigorous). The participants underwent 2 hours of a personalized cold exposure to determine the cold-induced BAT volume and activity and the skeletal muscles activity by means of an 18F-fluorodeoxyglucose positron emission tomography combined with a CT scan. Results: Objectively measured PA intensity levels were neither associated with BAT volume and activity nor with the skeletal muscles activity (all P > 0.05). The results remained after adjusting for sex, waking time, and environmental temperature. Conclusions: Although PA plays an important role in the prevention of obesity and related comorbidities, it seems that other physiological mechanisms rather than brown adipocyte activation or recruitment might moderate its beneficial metabolic effects in young sedentary adults.
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Authors: P Motiani; J Teuho; T Saari; K A Virtanen; S M Honkala; R J Middelbeek; L J Goodyear; O Eskola; J Andersson; E Löyttyniemi; J C Hannukainen; P Nuutila Journal: Obes Sci Pract Date: 2019-04-24
Authors: Almudena Carneiro-Barrera; Francisco J Amaro-Gahete; Francisco M Acosta; Jonatan R Ruiz Journal: J Clin Med Date: 2020-05-21 Impact factor: 4.241
Authors: Francisco M Acosta; Guillermo Sanchez-Delgado; Borja Martinez-Tellez; Jairo H Migueles; Francisco J Amaro-Gahete; Patrick C N Rensen; Jose M Llamas-Elvira; Denis P Blondin; Jonatan R Ruiz Journal: Sleep Date: 2019-12-24 Impact factor: 5.849
Authors: Guillermo Sanchez-Delgado; Francisco M Acosta; Borja Martinez-Tellez; Graham Finlayson; Catherine Gibbons; Idoia Labayen; Jose M Llamas-Elvira; Angel Gil; John E Blundell; Jonatan R Ruiz Journal: Am J Clin Nutr Date: 2020-02-01 Impact factor: 7.045
Authors: Francisco J Amaro-Gahete; Lucas Jurado-Fasoli; Guillermo Sanchez-Delgado; José V García-Lario; Manuel J Castillo; Jonatan R Ruiz Journal: Aging (Albany NY) Date: 2020-01-20 Impact factor: 5.682
Authors: Anna Straburzyńska-Lupa; Tomasz Cisoń; Marta Gomarasca; Anna Babińska; Giuseppe Banfi; Giovanni Lombardi; Ewa Śliwicka Journal: Sci Rep Date: 2021-08-09 Impact factor: 4.379