Mohammad Taghi Hedayati1,2, Mahin Tavakoli2,3, Fateme Zakavi4, Tahereh Shokohi1,2, Ramin Mofarrah5, Saham Ansari6, Mojtaba Taghizadeh Armaki7. 1. Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran. 2. Department of Medical Parasitology and Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. 3. Student Research Committee, Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran. 4. Polyclinic Laboratory, Social Security Administration of Amole, Amole, Iran. 5. Department of Dermatology, Faculty of Medicine, Islamic Azad University, Sari Branch, Sari, Iran. 6. Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 7. Department of Medical Parasitology and Mycology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Abstract
INTRODUCTION: This study aims to evaluate the antifungal susceptibility of different species of Candida isolated from diabetic patients against eight antifungal agents. METHODS: Susceptibility testing of 111 clinical isolates of Candida species was performed against 8 antifungals using the M27-A3 protocol of the Clinical and Laboratory Standards Institute (CLSI). RESULTS: Voriconazole, lanoconazole, and caspofungin showed the highest in vitro activity against all the isolates of C. albicans. Resistance against the tested antifungals was only observed in the C. albicans isolates. CONCLUSIONS: Our finding revealed that resistance against amphotericin B, itraconazole, ketoconazole, posaconazole, and fluconazole can be observed in C. albicans.
INTRODUCTION: This study aims to evaluate the antifungal susceptibility of different species of Candida isolated from diabeticpatients against eight antifungal agents. METHODS: Susceptibility testing of 111 clinical isolates of Candida species was performed against 8 antifungals using the M27-A3 protocol of the Clinical and Laboratory Standards Institute (CLSI). RESULTS:Voriconazole, lanoconazole, and caspofungin showed the highest in vitro activity against all the isolates of C. albicans. Resistance against the tested antifungals was only observed in the C. albicans isolates. CONCLUSIONS: Our finding revealed that resistance against amphotericin B, itraconazole, ketoconazole, posaconazole, and fluconazole can be observed in C. albicans.
Authors: Anna Biernasiuk; Anna Berecka-Rycerz; Anna Gumieniczek; Maria Malm; Krzysztof Z Łączkowski; Jolanta Szymańska; Anna Malm Journal: Appl Microbiol Biotechnol Date: 2021-08-19 Impact factor: 4.813