Huijun Chen1, Xiaoqian Luan1, Kai Zhao2, Huihua Qiu1, Yuntao Liu1, Xinjie Tu1, Wenjie Tang3, Jincai He4. 1. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. 2. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; First School of Clinical Medicine, Wenzhou Medical University, Wenzhou 325000, China. 3. First School of Clinical Medicine, Wenzhou Medical University, Wenzhou 325000, China. Electronic address: 13606777777@qq.com. 4. Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: hjc@wmu.edu.cn.
Abstract
BACKGROUND: Post-stroke depression (PSD) is the most common complication occurring among stroke survivors. It has been shown that increased neutrophil-to-lymphocyte ratio (NLR) is associated with depression. We explored the relationship between NLR and PSD. METHODS: In total, 299 ischemic stroke patients were consecutively enrolled in the study and received 1 month follow-up. The 17-Hamilton Rating Scale was used to measure depressive symptoms at 1 month after stroke. With the Hamilton Depression Scale score of >7, parents were given the DSM-IV criteria for diagnosis of PSD. NLR was computered from the admission blood work. Meanwhile, the control group consisted of 180 healthy volunteers was also recruited. RESULTS: Seventy-eight patients (26.1%) were diagnosed with PSD at 1 month. PSD patients showed significantly higher levels of NLRs at admission as compared to non-PSD patients as well as normal controls (P < .001). In the logistic analysis, taking NLR values (<3.701) a reference and PSD presence as a dependent variable, NLR values (≥3.70 l) were independently associated with the development of PSD (OR 4.038, 95% CI 2.174-7.500, p < .001). CONCLUSIONS: Increased NLRs at admission are found to be correlated with PSD and may add prognostic information for the early discovery of PSD.
BACKGROUND: Post-stroke depression (PSD) is the most common complication occurring among stroke survivors. It has been shown that increased neutrophil-to-lymphocyte ratio (NLR) is associated with depression. We explored the relationship between NLR and PSD. METHODS: In total, 299 ischemic strokepatients were consecutively enrolled in the study and received 1 month follow-up. The 17-Hamilton Rating Scale was used to measure depressive symptoms at 1 month after stroke. With the Hamilton Depression Scale score of >7, parents were given the DSM-IV criteria for diagnosis of PSD. NLR was computered from the admission blood work. Meanwhile, the control group consisted of 180 healthy volunteers was also recruited. RESULTS: Seventy-eight patients (26.1%) were diagnosed with PSD at 1 month. PSDpatients showed significantly higher levels of NLRs at admission as compared to non-PSDpatients as well as normal controls (P < .001). In the logistic analysis, taking NLR values (<3.701) a reference and PSD presence as a dependent variable, NLR values (≥3.70 l) were independently associated with the development of PSD (OR 4.038, 95% CI 2.174-7.500, p < .001). CONCLUSIONS: Increased NLRs at admission are found to be correlated with PSD and may add prognostic information for the early discovery of PSD.