OBJECTIVE: In adults, certain body fat depots have greater impact on cardiometabolic risk than total adiposity. Whether similar relationships exist in children is uncertain. The aim of this study was to examine the relationships among dual x-ray absorptiometry (DXA) measures of body fat distribution and total body adiposity with cardiometabolic risk factors in Hispanic girls. METHODS: Measures of total percent body fat, percent of total fat within the android, gynoid, leg, and trunk regions, and cardiometabolic biomarkers (insulin, glucose, homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides (TG), low and high lipoprotein cholesterol (LDL-C, HDL-C)) were obtained from 232 Hispanic girls (age 10.7 ±1.1 years). Regression models for each metabolic parameter were run against adiposity measures. Partial correlations of the adiposity measures were used to compare associations between adiposity measures and the cardiometabolic risk factors, controlling for somatic maturation. RESULTS: Total and regional adiposity were significantly related with cardiometabolic risk factors (P < 0.05) except fasting glucose. The partial correlations of total and regional adiposity measures with each cardiometabolic biomarker were similar. More variance was explained for insulin and the HOMA-IR (33%-43%) than other risk factors. Partial correlations for the percentage of total fat in the gynoid and leg regions with insulin, HOMA-IR, TG, and LDL-C were negative, and positive with HDL-C. CONCLUSION: Measures of total and regional fat perform similarly in predicting cardiometabolic risk in Hispanic girls. A higher proportion of fat distributed in the gynoid or leg region is associated with lower cardiometabolic risk.
OBJECTIVE: In adults, certain body fat depots have greater impact on cardiometabolic risk than total adiposity. Whether similar relationships exist in children is uncertain. The aim of this study was to examine the relationships among dual x-ray absorptiometry (DXA) measures of body fat distribution and total body adiposity with cardiometabolic risk factors in Hispanic girls. METHODS: Measures of total percent body fat, percent of total fat within the android, gynoid, leg, and trunk regions, and cardiometabolic biomarkers (insulin, glucose, homeostatic model assessment of insulin resistance (HOMA-IR), triglycerides (TG), low and high lipoprotein cholesterol (LDL-C, HDL-C)) were obtained from 232 Hispanic girls (age 10.7 ±1.1 years). Regression models for each metabolic parameter were run against adiposity measures. Partial correlations of the adiposity measures were used to compare associations between adiposity measures and the cardiometabolic risk factors, controlling for somatic maturation. RESULTS: Total and regional adiposity were significantly related with cardiometabolic risk factors (P < 0.05) except fasting glucose. The partial correlations of total and regional adiposity measures with each cardiometabolic biomarker were similar. More variance was explained for insulin and the HOMA-IR (33%-43%) than other risk factors. Partial correlations for the percentage of total fat in the gynoid and leg regions with insulin, HOMA-IR, TG, and LDL-C were negative, and positive with HDL-C. CONCLUSION: Measures of total and regional fat perform similarly in predicting cardiometabolic risk in Hispanic girls. A higher proportion of fat distributed in the gynoid or leg region is associated with lower cardiometabolic risk.
Authors: M Sánchez-López; F B Ortega; P Moya-Martínez; S López-Martínez; I Ortiz-Galeano; M A Gómez-Marcos; M Sjöström; V Martínez-Vizcaíno Journal: Eur J Nutr Date: 2012-04-07 Impact factor: 5.614
Authors: Scott Going; Timothy Lohman; Linda Houtkooper; Lauve Metcalfe; Hilary Flint-Wagner; Robert Blew; Vanessa Stanford; Ellen Cussler; Jane Martin; Pedro Teixeira; Margaret Harris; Laura Milliken; Arturo Figueroa-Galvez; Judith Weber Journal: Osteoporos Int Date: 2003-07-03 Impact factor: 4.507
Authors: Eliane Rodrigues de Faria; Sylvia do Carmo C Franceschini; Maria do Carmo G Peluzio; Luciana Ferreira da R Sant'Ana; Silvia Eloiza Priore Journal: Rev Paul Pediatr Date: 2013-09
Authors: Binghan Jin; Hu Lin; Jinna Yuan; Guanping Dong; Ke Huang; Wei Wu; Xuefeng Chen; Li Zhang; Jinling Wang; Xinyi Liang; Yangli Dai; Xiaoqin Xu; Xuelian Zhou; Mingqiang Zhu; Guohua Li; Wayne S Cutfield; Paul L Hofman; José G B Derraik; Junfen Fu Journal: Front Endocrinol (Lausanne) Date: 2020-09-04 Impact factor: 5.555