BACKGROUND: Systemic lupus erythematosus is prone to recurrent attacks, and its treatment is related to disease activities. It is important to accurately assess the patient's disease activity. So, the purpose of this study was to investigate the relation between neutrophil-to-C3 ratio (NC3 R), neutrophil-to-lymphocyte ratio (NLR), and disease activity in patients with Systemic lupus erythematosus (SLE). METHODS: This was a retrospective study. One hundred and ninety-four patients with SLE and 71 healthy controls were included in this study. We divided the patients into two groups according to the SLE disease activity (SLEDAI). Group 1 included patients with a score of >9 (patients with severe disease activity), and Group 2 included patients with a score of 9 and lower (patients with mild disease activity). Correlations between NC3 R, NLR, and disease activity were analyzed. RESULTS: NC3 R and NLR in patients with SLE were obviously higher compared to healthy controls (P < 0.05). There was an obviously significant difference in NC3 R and NLR between Group 1 and Group 2 (P < 0.05). SLEDAI scores were positively correlated with NC3 R (r = 0.353, P < 0.01) and NLR (r = 0.237, P = 0.01). Receiver operating characteristic (ROC) curve analysis showed that the cutoff value of NC3 R to identify SLE with high disease activity was 5.935, with sensitivity and specificity being 75.9% and 67.0%, while that of NLR was 2.293, with sensitivity being 68.9% and specificity being 82.8%. CONCLUSION: NC3 R and NLR are two useful inflammatory markers for evaluating disease activity in patients with SLE.
BACKGROUND:Systemic lupus erythematosus is prone to recurrent attacks, and its treatment is related to disease activities. It is important to accurately assess the patient's disease activity. So, the purpose of this study was to investigate the relation between neutrophil-to-C3 ratio (NC3 R), neutrophil-to-lymphocyte ratio (NLR), and disease activity in patients with Systemic lupus erythematosus (SLE). METHODS: This was a retrospective study. One hundred and ninety-four patients with SLE and 71 healthy controls were included in this study. We divided the patients into two groups according to the SLE disease activity (SLEDAI). Group 1 included patients with a score of >9 (patients with severe disease activity), and Group 2 included patients with a score of 9 and lower (patients with mild disease activity). Correlations between NC3 R, NLR, and disease activity were analyzed. RESULTS: NC3 R and NLR in patients with SLE were obviously higher compared to healthy controls (P < 0.05). There was an obviously significant difference in NC3 R and NLR between Group 1 and Group 2 (P < 0.05). SLEDAI scores were positively correlated with NC3 R (r = 0.353, P < 0.01) and NLR (r = 0.237, P = 0.01). Receiver operating characteristic (ROC) curve analysis showed that the cutoff value of NC3 R to identify SLE with high disease activity was 5.935, with sensitivity and specificity being 75.9% and 67.0%, while that of NLR was 2.293, with sensitivity being 68.9% and specificity being 82.8%. CONCLUSION: NC3 R and NLR are two useful inflammatory markers for evaluating disease activity in patients with SLE.
Authors: Malte A Kluger; Simon Melderis; Anna Nosko; Boeren Goerke; Michael Luig; Matthias C Meyer; Jan-Eric Turner; Catherine Meyer-Schwesinger; Claudia Wegscheid; Gisa Tiegs; Rolf A K Stahl; Ulf Panzer; Oliver M Steinmetz Journal: Kidney Int Date: 2016-01-04 Impact factor: 10.612
Authors: Michelle Petri; Ana-Maria Orbai; Graciela S Alarcón; Caroline Gordon; Joan T Merrill; Paul R Fortin; Ian N Bruce; David Isenberg; Daniel J Wallace; Ola Nived; Gunnar Sturfelt; Rosalind Ramsey-Goldman; Sang-Cheol Bae; John G Hanly; Jorge Sánchez-Guerrero; Ann Clarke; Cynthia Aranow; Susan Manzi; Murray Urowitz; Dafna Gladman; Kenneth Kalunian; Melissa Costner; Victoria P Werth; Asad Zoma; Sasha Bernatsky; Guillermo Ruiz-Irastorza; Munther A Khamashta; Soren Jacobsen; Jill P Buyon; Peter Maddison; Mary Anne Dooley; Ronald F van Vollenhoven; Ellen Ginzler; Thomas Stoll; Christine Peschken; Joseph L Jorizzo; Jeffrey P Callen; S Sam Lim; Barri J Fessler; Murat Inanc; Diane L Kamen; Anisur Rahman; Kristjan Steinsson; Andrew G Franks; Lisa Sigler; Suhail Hameed; Hong Fang; Ngoc Pham; Robin Brey; Michael H Weisman; Gerald McGwin; Laurence S Magder Journal: Arthritis Rheum Date: 2012-08
Authors: Daniel J Birmingham; Joshua E Bitter; Ezinne G Ndukwe; Sarah Dials; Terese R Gullo; Sara Conroy; Haikady N Nagaraja; Brad H Rovin; Lee A Hebert Journal: Clin J Am Soc Nephrol Date: 2015-12-23 Impact factor: 8.237
Authors: Andrew J Monteith; SunAh Kang; Eric Scott; Kai Hillman; Zenon Rajfur; Ken Jacobson; M Joseph Costello; Barbara J Vilen Journal: Proc Natl Acad Sci U S A Date: 2016-03-28 Impact factor: 11.205
Authors: Daniel Toro-Domínguez; Raúl Lopez-Domínguez; Adrián García Moreno; Juan A Villatoro-García; Jordi Martorell-Marugán; Daniel Goldman; Michelle Petri; Daniel Wojdyla; Bernardo A Pons-Estel; David Isenberg; Gabriela Morales-Montes de Oca; María Isabel Trejo-Zambrano; Benjamín García González; Florencia Rosetti; Diana Gómez-Martín; Juanita Romero-Díaz; Pedro Carmona-Sáez; Marta E Alarcón-Riquelme Journal: Sci Rep Date: 2019-10-29 Impact factor: 4.379