Literature DB >> 30125678

Advancing precision medicine with personalized drug screening.

Kirill Gorshkov1, Catherine Z Chen1, Raisa E Marshall2, Nino Mihatov2, Yong Choi2, Dac-Trung Nguyen1, Noel Southall1, Kevin G Chen2, John K Park2, Wei Zheng3.   

Abstract

Personalized drug screening (PDS) of approved drug libraries enables rapid development of specific small-molecule therapies for individual patients. With a multidisciplinary team including clinicians, researchers, ethicists, informaticians and regulatory professionals, patient treatment can be optimized with greater efficacy and fewer adverse effects by using PDS as an approach to find remedies. In addition, PDS has the potential to rapidly identify therapeutics for a patient suffering from a disease without an existing therapy. From cancer to bacterial infections, we review specific maladies addressed with PDS campaigns. We predict that PDS combined with personal genomic analyses will contribute to the development of future precision medicine endeavors. Published by Elsevier Ltd.

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Year:  2018        PMID： 30125678      PMCID： PMC6372320          DOI： 10.1016/j.drudis.2018.08.010

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  44 in total

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Journal:  Clin Cancer Res       Date:  2016-06-03       Impact factor: 12.531

6.  A functional CFTR assay using primary cystic fibrosis intestinal organoids.

Authors:  Johanna F Dekkers; Caroline L Wiegerinck; Hugo R de Jonge; Inez Bronsveld; Hettie M Janssens; Karin M de Winter-de Groot; Arianne M Brandsma; Nienke W M de Jong; Marcel J C Bijvelds; Bob J Scholte; Edward E S Nieuwenhuis; Stieneke van den Brink; Hans Clevers; Cornelis K van der Ent; Sabine Middendorp; Jeffrey M Beekman
Journal:  Nat Med       Date:  2013-06-02       Impact factor: 53.440

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8.  Epidemiology and burden of multidrug-resistant bacterial infection in a developing country.

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9.  Efficient and simple approach to in vitro culture of primary epithelial cancer cells.

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Journal:  Biosci Rep       Date:  2016-12-09       Impact factor: 3.840

10.  The exposome and the future of epidemiology: a vision and prospect.

Authors:  Kyoung-Nam Kim; Yun-Chul Hong
Journal:  Environ Health Toxicol       Date:  2017-05-03
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  8 in total

Review 1.  Pharmacological analysis of CFTR variants of cystic fibrosis using stem cell-derived organoids.

Authors:  Kevin G Chen; Pingyu Zhong; Wei Zheng; Jeffrey M Beekman
Journal:  Drug Discov Today       Date:  2019-06-04       Impact factor: 7.851

2.  Artificial Intelligence and Personalized Medicine.

Authors:  Nicholas J Schork
Journal:  Cancer Treat Res       Date:  2019

3.  Esophagus tissue engineering: from decellularization to in vivo recellularization in two sites.

Authors:  Sahar Eftekharzadeh; Aram Akbarzadeh; Nastaran Sabetkish; Minoo Rostami; Amir Hossein Zabolian; Javad Hashemi; Seyed Mohammad Tavangar; Abdol-Mohammad Kajbafzadeh
Journal:  Cell Tissue Bank       Date:  2021-08-19       Impact factor: 1.522

Review 4.  Induced pluripotent stem cells for neural drug discovery.

Authors:  Atena Farkhondeh; Rong Li; Kirill Gorshkov; Kevin G Chen; Matthew Might; Steven Rodems; Donald C Lo; Wei Zheng
Journal:  Drug Discov Today       Date:  2019-01-18       Impact factor: 7.851

Review 5.  Drug combination therapy for emerging viral diseases.

Authors:  Zeenat A Shyr; Yu-Shan Cheng; Donald C Lo; Wei Zheng
Journal:  Drug Discov Today       Date:  2021-05-21       Impact factor: 7.851

6.  C-MORE: A high-content single-cell morphology recognition methodology for liquid biopsies toward personalized cardiovascular medicine.

Authors:  Jennifer Furkel; Maximilian Knoll; Shabana Din; Nicolai V Bogert; Timon Seeger; Norbert Frey; Amir Abdollahi; Hugo A Katus; Mathias H Konstandin
Journal:  Cell Rep Med       Date:  2021-11-03

7.  Robot technology identifies a Parkinsonian therapeutics repurpose to target stem cells of glioblastoma.

Authors:  Andres Vargas-Toscano; Dilaware Khan; Ann-Christin Nickel; Michael Hewera; Marcel Alexander Kamp; Igor Fischer; Hans-Jakob Steiger; Wei Zhang; Sajjad Muhammad; Daniel Hänggi; Ulf Dietrich Kahlert
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8.  "Direct to Drug" screening as a precision medicine tool in multiple myeloma.

Authors:  Cecilia Bonolo de Campos; Nathalie Meurice; Joachim L Petit; Alysia N Polito; Yuan Xiao Zhu; Panwen Wang; Laura A Bruins; Xuewei Wang; Ilsel D Lopez Armenta; Susie A Darvish; Greg J Ahmann; Kimberly J Henderson; Shulan Tian; Jonas J Kruse; William M Stewart; Jeremy T Larsen; Craig B Reeder; David Dingli; Prashant Kapoor; Shaji K Kumar; Rafael Fonseca; P Leif Bergsagel; Esteban Braggio; A Keith Stewart
Journal:  Blood Cancer J       Date:  2020-05-11       Impact factor: 11.037
  8 in total

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