Miki Takahashi1, Nana Kosaka2, Emi Wakui1, Shinobu Iwaki1, Mika Nishii1, Masanori Teshima3, Hirotaka Shinomiya3, Koichi Morimoto3, Naomi Kiyota4, Ryohei Sasaki5, Makoto Usami2, Naoki Otsuki6, Ken-Ichi Nibu3. 1. Department of Rehabilitation, Kobe University Hospital, Kobe, Japan. 2. Division of Nutrition and Metabolism, Kobe University Graduate School of Health Sciences, Kobe, Japan. 3. Department of Otolaryngology-Head and Neck Surgery, Kobe University Hospital, Kobe, Japan. 4. Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan. 5. Department of Radiation Oncology, Kobe University Hospital, Kobe, Japan. 6. Department of Otolaryngology-Head and Neck Surgery, Kobe University Hospital, Kobe, Japan. naokies@med.kobe-u.ac.jp.
Abstract
BACKGROUND: Concomitant chemoradiotherapy (CCRT) produces severe mucositis and swallowing dysfunction, often resulting in malnutrition. Intensive nutrition support (INS) in addition to percutaneous endoscopic gastrostomy (PEG) is reported to decrease adverse effects during CCRT. PATIENTS AND METHODS: Fifty-eight patients with oropharyngeal cancer treated by CDDP-based CCRT were retrospectively analyzed. Twenty-nine patients treated with INS in addition to PEG were classified as INS group, and other 29 patients treated with PEG but without INS were classified as control group. RESULTS: INS in addition to PEG significantly increased calorie intake in the second half of CCRT and reduced adverse events including mucositis (p = 0.0019), leukopenia (p = 0.04), and renal function (p = 0.006). Moreover, 21 out of 29 patients had successfully administration of 200 mg/m2 or more of CDDP, while only 10 out of 29 patients had enough amount of CDDP in control group. CONCLUSIONS: These results suggest that INS in addition to prophylactic PEG not only decreases adverse effects but also may potentially improve oncological outcome of the patients with oropharyngeal cancer treated by CCRT.
BACKGROUND: Concomitant chemoradiotherapy (CCRT) produces severe mucositis and swallowing dysfunction, often resulting in malnutrition. Intensive nutrition support (INS) in addition to percutaneous endoscopic gastrostomy (PEG) is reported to decrease adverse effects during CCRT. PATIENTS AND METHODS: Fifty-eight patients with oropharyngeal cancer treated by CDDP-based CCRT were retrospectively analyzed. Twenty-nine patients treated with INS in addition to PEG were classified as INS group, and other 29 patients treated with PEG but without INS were classified as control group. RESULTS:INS in addition to PEG significantly increased calorie intake in the second half of CCRT and reduced adverse events including mucositis (p = 0.0019), leukopenia (p = 0.04), and renal function (p = 0.006). Moreover, 21 out of 29 patients had successfully administration of 200 mg/m2 or more of CDDP, while only 10 out of 29 patients had enough amount of CDDP in control group. CONCLUSIONS: These results suggest that INS in addition to prophylactic PEG not only decreases adverse effects but also may potentially improve oncological outcome of the patients with oropharyngeal cancer treated by CCRT.
Authors: Giorgio Capuano; Alessandra Grosso; Pier Carlo Gentile; Michele Battista; Federico Bianciardi; Annamaria Di Palma; Ida Pavese; Francesco Satta; Michela Tosti; Anna Palladino; Guido Coiro; Mario Di Palma Journal: Head Neck Date: 2008-04 Impact factor: 3.147
Authors: Kristin Lang; Rami A ElShafie; Sati Akbaba; Ronald Koschny; Nina Bougatf; Denise Bernhardt; Stefan E Welte; Sebastian Adeberg; Matthias Häfner; Steffen Kargus; Peter K Plinkert; Jürgen Debus; Stefan Rieken Journal: Cancer Manag Res Date: 2020-01-08 Impact factor: 3.989