| Literature DB >> 30121451 |
Alexandra J Mably1, Laura Lee Colgin2.
Abstract
Gamma oscillations (∼25-100 Hz) are believed to play a role in cognition. Accordingly, aberrant gamma oscillations have been observed in several cognitive disorders, including Alzheimer's disease and Fragile X syndrome. Here, we review how recent results showing abnormal gamma rhythms in Alzheimer's disease and Fragile X syndrome help reveal links between cellular disturbances and cognitive impairments. We also discuss how gamma results from rodent models of Alzheimer's disease and Fragile X syndrome may provide insights about unique functions of distinct slow (∼25-50 Hz) and fast gamma (∼55-100 Hz) subtypes. Finally, we consider studies employing brain stimulation paradigms in Alzheimer's disease and discuss how such studies may reveal causal relationships between gamma impairments and memory disturbances.Entities:
Mesh:
Year: 2018 PMID: 30121451 PMCID: PMC6139067 DOI: 10.1016/j.conb.2018.07.009
Source DB: PubMed Journal: Curr Opin Neurobiol ISSN: 0959-4388 Impact factor: 6.627